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Since <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>akasaki et\u2009al. introduced <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> for locally advanced gallbladder cancer in 1980, <jats:styled-content style=\"fixed-case\">Japanese<\/jats:styled-content> hepatobiliary surgeons have aggressively challenged this extended procedure for advanced biliary tumors. Early experiences with <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> were frequently associated with liver failure and sequential mortality, leading to an underestimation of the survival benefit of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content>. However, with improvements in surgical techniques and perioperative patient care, including portal vein embolization, over the last two decades, the mortality rate after <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> has gradually decreased. Recent studies have demonstrated a favorable survival in cholangiocarcinoma, provided that R0 resection is achieved. In contrast, <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> for gallbladder cancer remains controversial because of the extremely poor survival, although the study populations have been limited. <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> can be performed with low mortality and offers a better probability of long\u2010term survival in patients with cholangiocarcinoma. We should consider <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> to be a standard approach for laterally advanced cholangiocarcinomas that are otherwise unresectable.<\/jats:p>","DOI":"10.1002\/jhbp.80","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T09:41:45Z","timestamp":1390815705000},"page":"550-555","source":"Crossref","is-referenced-by-count":49,"title":["Review of hepatopancreatoduodenectomy for biliary cancer: an extended radical approach of <scp>J<\/scp>apanese origin"],"prefix":"10.1002","volume":"21","author":[{"given":"Tomoki","family":"Ebata","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Nagoya University Graduate School of Medicine  65 Tsurumai\u2010cho, Showa\u2010ku Nagoya 466\u20108550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Surgical 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