{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:51:48Z","timestamp":1769629908782,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curative resection and define the \u201chigh\u2010risk\u201d group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of patients who underwent curative resection for AoV carcinoma in four hospitals, namely Yonsei Gangnam Severance Hospital, Seoul National University Hospital, Seoul National University Bundang Hospital, and National Cancer Center (n\u00a0=\u00a0651; 2002\u20132015), were reviewed. Overall survival (OS) and recurrence\u2010free survival (RFS) rates were compared using Kaplan\u2013Meier estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data of 651 patients who had undergone curative resection were retrospectively reviewed. Age, T stage, N stage, and differentiation type remained strong and independent risk factors for RFS and OS. In early\u2010stage AoV carcinoma (T1N0, T2N0), the non\u2010adjuvant group had better prognosis based on the RFS and OS than the adjuvant group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007). In advanced T stage (T3N0, T4N0), the adjuvant group had better prognosis than the non\u2010adjuvant group, but the difference was not statistically significant (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). In node\u2010positive patients (any T, N1\/2), adjuvant treatment did not affect RFS and OS (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adjuvant treatment after curative resection of AoV carcinoma is not associated with improved survival. The high\u2010risk group (node\u2010positive or advanced T stage (T3, T4)) treated with adjuvant treatment was not statistically associated with improved survival; however, our study showed that the adjuvant treatment for the high\u2010risk group might help achieve better patient outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.801","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T19:20:45Z","timestamp":1594495245000},"page":"721-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9002-3569","authenticated-orcid":false,"given":"Hyung Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, Pancreatobiliary Cancer Clinic, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-0503","authenticated-orcid":false,"given":"Jin\u2010Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-8557","authenticated-orcid":false,"given":"Yoo\u2010Seok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University Bundang Hospital Seoul National University Seoul 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