{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:19:45Z","timestamp":1789057185640,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>The aim of the present study was to identify the types of recurrence in pancreatic ductal adenocarcinoma (PDAC) and discover the frequent location of the local recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 361 patients with PDAC who underwent curative\u2010intent surgery between 2007\u20102014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 361 patients, 75.1% (n\u00a0=\u00a0271) developed recurrence during the follow\u2010up period. The 5\u2010year overall survival rate of recurred patients was 8.3%. The patterns of recurrence were classified as local (17.7%), systemic (62.0%), and loco\u2010systemic (20.3%). According to the preoperative tumor locations, patients with uncinate and head cancer showed higher rates of local recurrence than those with body and tail cancer (47.8% vs 17.2%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). When comparing uncinate and head cancer only, patients with uncinate cancer had much more frequent local recurrence around the superior mesenteric artery\/vein (M zone) than around the hepatoduodenal ligament\/common hepatic artery (H zone). Patients with head cancer had a higher rate of local recurrence in the H zone (H zone vs M zone; 53.5% vs 81.4% in uncinate cancer, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001; 66.7% vs 44.4% in head cancer, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.056).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Discovering the patterns of recurrence and frequent locations of recurrence may assist in local control as well as in the development of a customized individual approach for each patient.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.854","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T09:59:19Z","timestamp":1603274359000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pattern of local recurrence after curative resection in pancreatic ductal adenocarcinoma according to the initial location of the tumor"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-1350","authenticated-orcid":false,"given":"Jae Ri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"},{"name":"Department of Surgery Pusan National University Hospital Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbeom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooil","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-6019","authenticated-orcid":false,"given":"Sun\u2010Whe","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul South Korea"},{"name":"Center for Liver and Pancreatobiliary Cancer National Cancer Center Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0384-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0295-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-010-0593-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481007600514"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900215"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032295"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181613142"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1165-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2012.1126"},{"key":"e_1_2_6_12_1","first-page":"1756","article-title":"Pattern of first recurrent lesions in pancreatic cancer: hepatic relapse is associated with dismal prognosis and portal vein invasion","volume":"61","author":"Suenaga M","year":"2014","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.205.2.9356640"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i24.7864"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000384"},{"key":"e_1_2_6_16_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology. 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