{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:38:07Z","timestamp":1776886687425,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Red dichromatic imaging (RDI) is next\u2010generation image\u2010enhanced endoscopy technique released in July 2020. We previously reported that RDI can predict esophageal varices (EV) depth and decrease their recurrence rate by accurate intravariceal injections during endoscopic injection sclerotherapy (EIS) using unreleased prototype RDI endoscope. In this study, we analyzed whether RDI improves the overall survival (OS) rate and whether it is more accurate independent predictor of EV recurrence than white light imaging (WLI), using propensity score matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 179 patients were enrolled. Patients were matched for age, platelet count, liver function, EV size, luminal diameter, and EV depth using propensity score matching, and 78 patients (RDI, 39; WLI, 39) were finally matched. Primary endpoints were OS and recurrence rates. Secondary endpoints were success rate of intravariceal injection, operating time, incidence of adverse events (AEs), and predictors associated with OS and recurrence rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.193), but the cumulative recurrence rate in the RDI group was significantly lower than in the WLI group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). Success rates of intrainjection, operating time, and incidence of AEs were better in the RDI group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.035, .026, and .0019, respectively). Independent predictors associated with recurrence rate by Cox proportional regression were RDI function and luminal diameter (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and .017, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RDI did not improve OS but decreased the recurrence rate. Independent predictors of recurrence rate were RDI and luminal diameter, resulting from secure intravariceal injections in EIS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.894","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T16:20:37Z","timestamp":1610814037000},"page":"431-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Secure intravariceal sclerotherapy with red dichromatic imaging decreases the recurrence rate of esophageal varices: A propensity score matching analysis"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8986-9823","authenticated-orcid":false,"given":"Yoshihiro","family":"Furuichi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan"},{"name":"Department of Gastroenterology Niiza Shiki Central General Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-3216","authenticated-orcid":false,"given":"Masakazu","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-6166","authenticated-orcid":false,"given":"Yoshitaka","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-3202","authenticated-orcid":false,"given":"Hirohito","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-2294","authenticated-orcid":false,"given":"Yuu","family":"Yoshimasu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-8437","authenticated-orcid":false,"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.281.hpc"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23258"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.593"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.06.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30077-7"},{"key":"e_1_2_7_8_1","first-page":"305","article-title":"Esophagogastric varices predict mortality in hospitalized patients with alcoholic liver disease in Taiwan","volume":"57","author":"Lin CW","year":"2010","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004649901045"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.119500"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.06.032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1249-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010403"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306502"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018913"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2009.00929.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13632"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03376.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.16786"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2017.06"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i26.4806"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2019.18334"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.2.264"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208903"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/1319-3767.164185","article-title":"Correlation of HVPG level with ctp score, MELD Score, ascites, size of varices, and etiology in cirrhotic patients","volume":"22","author":"Ramanathan S","year":"2016","journal-title":"Saudi J Gastroenterol"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80248-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750024841"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80064-1"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70036-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41864.x"},{"key":"e_1_2_7_32_1","first-page":"599","article-title":"Prospective controlled study of para\u2010 and intravariceal sclerosing therapy of esophageal varices","volume":"114","author":"Witzel L","year":"1984","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_7_33_1","first-page":"706","article-title":"Combined injection method by para and intra\u2010variceal injection. Instrument and practice of technique","volume":"48","author":"Hayakawa K","year":"1990","journal-title":"Nihon Rinsho"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.894","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhbp.894","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T17:14:08Z","timestamp":1693502048000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/jhbp.894"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.894","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"2020-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}