{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:18:40Z","timestamp":1770754720161,"version":"3.50.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In cases of acute cholecystitis (AC), empirical antibiotics are used to prevent infectious morbidities following cholecystectomy. However, there are still no exact guidelines on which antibiotics to use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 300 patients who had been admitted for cholecystectomy because of grade I or II AC. We randomly allocated them to one of two groups empirically: the first group was to be given first\u2010generation cephalosporins (group I, 150 patients) and the second group was to be given second\u2010generation cephalosporins (group II, 150 patients). We analyzed the clinical outcomes and the incidence of postoperative infectious morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate of overall infectious morbidities (18 cases, 12% in group I; 17 cases, 11.3% in group II; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.859) showed no difference between the two groups. The incidence rate of sepsis (only one case, 0.7% in group II, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.000) or surgical site infection (nine cases, 6% in group I and eight cases, 5.3% in group II, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.000) were also similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The empirical use of first\u2010generation cephalosporins for mild\u2010to\u2010moderate AC without gallbladder perforation was not inferior to using second\u2010generation cephalosporin for prophylaxis against postoperative infection. Our results could allow for a tailored treatment strategy of empirical antibiotics according to the severity of the cholecystitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.926","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T02:09:00Z","timestamp":1614564540000},"page":"848-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Empirical antibiotics for acute cholecystitis\u2014what generation of antibiotics is an appropriate choice? A prospective, randomized controlled study"],"prefix":"10.1002","volume":"28","author":[{"given":"Eun","family":"Young Kim","sequence":"first","affiliation":[{"name":"Department of Trauma and Surgical Critical Care Seoul St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-8104","authenticated-orcid":false,"given":"Tae","family":"Ho Hong","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010biliary and Pancreas Surgery Department of Surgery Seoul St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"165","article-title":"Gallstone disease and its complications","volume":"14","author":"Browning 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