{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:49:50Z","timestamp":1789753790436,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reflux of pancreatic enzymes into the bile duct and the gallbladder is an abnormal phenomenon that plays a role in lithogenesis and carcinogenesis. Because the pressure of the common bile duct depends on the pressures of the sphincter of Oddi, its dysfunction would be reflected in an increase in the pressure of the common bile duct in patients with cholelithiasis. The objective of this study was to measure the pressures of the common bile duct in patients with and without cholelithiasis and to relate them to the presence of pancreatobiliary reflux.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective case\u2010control study was designed. The study universe was constituted by all patients undergoing total gastrectomy for gastric cancer stages I and II over 30\u00a0months. The primary outcome measure was to establish differences between common bile duct pressures in patients with and without cholelithiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Common bile duct pressures in patients with gallstones showed a significant elevation (16.9\u00a0mmHg) compared to patients without gallstones (3.3\u00a0mm Hg) (p\u00a0&lt;\u00a00.0001). These pressures correlated with the levels of amylase and lipase in gallbladder bile; higher levels were found in patients with gallstones compared to patients without gallstones (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Common bile duct pressure in patients with cholelithiasis was significantly higher compared to patients without cholelithiasis leading to pancreatobiliary reflux.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.931","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T17:11:13Z","timestamp":1614359473000},"page":"443-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Common bile duct pressure in patients with and without cholelithiasis: A case\u2010control study"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-5480","authenticated-orcid":false,"given":"Marcelo A.","family":"Beltr\u00e1n","sequence":"first","affiliation":[{"name":"Department of Surgery Hospital San Juan de Dios de La Serena Coquimbo Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Medicine School Universidad de Santiago de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20756"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0771-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0718-40262011000100005"},{"key":"e_1_2_7_5_1","first-page":"953","article-title":"Pancreatobiliary reflux in patients with a 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