{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:03:33Z","timestamp":1784937813361,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>The relationship between autoimmune pancreatitis (AIP) and malignancy has been reported. However, the potential risk for cancer in patients with immunoglobulin 4 (IgG4)\u2010related sclerosing cholangitis (IgG4\u2010SC) is unclear. The present study aimed to evaluate the incidence of cancer in IgG4\u2010SC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected clinical data for 121 patients diagnosed with IgG4\u2010SC from 7 hospitals. We calculated the standardized incidence ratio (SIR) of cancer in IgG4\u2010SC patients based on the national cancer rates. The SIR of the period after the diagnosis of IgG4\u2010SC were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up period was 6.4\u00a0years, with 121 IgG4\u2010SC patients. During the follow\u2010up period, 26 patients had cancer, and 29 cancers were diagnosed. The SIR of cancer after the diagnosis of IgG4\u2010SC was 1.90 (95% confidence interval [CI] 1.67\u20102.21). The SIR of pancreatic and bile duct cancer was 10.30 and 8.88, respectively. The SIR of cancer in &lt;1\u00a0year, 1\u20105\u00a0years, and &gt;5\u00a0years after diagnosis of IgG4\u2010SC were 2.58, 1.01, and 2.44, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IgG4\u2010SC patients have a high risk of cancer including pancreatic and bile duct cancer. The risk of cancer was high less &lt;1\u00a0year and &gt;5\u00a0years after diagnosis of IgG4\u2010SC. Therefore, IgG4\u2010SC patients may require careful long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.957","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T01:45:28Z","timestamp":1619833528000},"page":"524-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["IgG4\u2010related sclerosing cholangitis may be a risk factor for cancer"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2482-6707","authenticated-orcid":false,"given":"Yusuke","family":"Kurita","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Medicine NTT Medical Center Tokyo Tokyo 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Gastroenterology Machida Municipal Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-0643","authenticated-orcid":false,"given":"Sho","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Hosono","sequence":"additional","affiliation":[{"name":"Department of 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