{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:20:52Z","timestamp":1788024052297,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["T32 HS026122"],"award-info":[{"award-number":["T32 HS026122"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08AR081405"],"award-info":[{"award-number":["K08AR081405"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1TR002244"],"award-info":[{"award-number":["TL1TR002244"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["shmpublications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multisystem inflammatory syndrome in children (MIS\u2010C) is a rare but serious complication of severe acute respiratory syndrome coronavirus 2 infection. Features of MIS\u2010C overlap with those of Kawasaki disease (KD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study objective was to develop a prediction model to assist with this diagnostic dilemma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from a retrospective cohort of children hospitalized with KD before the coronavirus disease 2019 pandemic were compared to a prospective cohort of children hospitalized with MIS\u2010C. A bootstrapped backwards selection process was used to develop a logistic regression model predicting the probability of MIS\u2010C diagnosis. A nomogram was created for application to individual patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to children with incomplete and complete KD (<jats:italic>N<\/jats:italic>\u2009=\u2009602), children with MIS\u2010C (<jats:italic>N<\/jats:italic>\u2009=\u2009105) were older and had longer hospitalizations; more frequent intensive care unit admissions and vasopressor use; lower white blood cell count, lymphocyte count, erythrocyte sedimentation rate, platelet count, sodium, and alanine aminotransferase; and higher hemoglobin and C\u2010reactive protein (CRP) at admission. Left ventricular dysfunction was more frequent in patients with MIS\u2010C, whereas coronary abnormalities were more common in those with KD. The final prediction model included age, sodium, platelet count, alanine aminotransferase, reduction in left ventricular ejection fraction, and CRP. The model exhibited good discrimination with AUC 0.96 (95% confidence interval: [0.94\u20130.98]) and was well calibrated (optimism\u2010corrected intercept of \u22120.020 and slope of 0.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A diagnostic prediction model utilizing admission information provides excellent discrimination between MIS\u2010C and KD. This model may be useful for diagnosis of MIS\u2010C but requires external validation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhm.13290","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T02:09:58Z","timestamp":1706494198000},"page":"175-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical prediction model: Multisystem inflammatory syndrome in children versus Kawasaki disease"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-9774","authenticated-orcid":false,"given":"Lauren S.","family":"Starnes","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University Medical Center Division of Pediatric Hospital Medicine Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Starnes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 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