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Yet, few patients receive pharmacotherapy consistent with guideline recommendations. Previous concerns over the potential hepatotoxicity of naltrexone have been disproven and recent studies have shown its safety and efficacy in patients with cirrhosis. Naltrexone is an effective therapy to reduce heavy alcohol consumption, however, lack of knowledge among prescribers inhibits greater uptake. Hospitalization is an opportune time for change\u2014naltrexone can promote the reduction or cessation of unhealthy alcohol consumption, as well as subsequent readmissions or progression of alcohol\u2010related liver disease. Hospitalists should stop avoiding naltrexone in the treatment of AUD.<\/jats:p>","DOI":"10.1002\/jhm.13569","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T05:59:56Z","timestamp":1733810396000},"page":"768-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Things We Do for No Reason\u2122: Avoiding naltrexone for alcohol use disorder in liver disease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-4957","authenticated-orcid":false,"given":"Dustin P.","family":"Kee","sequence":"first","affiliation":[{"name":"Department of Medicine Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Buyske","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-7783","authenticated-orcid":false,"given":"Susan L.","family":"Calcaterra","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine and Division of General Medicine, Department of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19761"},{"key":"e_1_2_7_3_1","volume-title":"Key Substance Use and Mental Health Indicators in the United States: Results From the 2021 National Survey on Drug Use and Health","author":"SAMHSA Administration","year":"2022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23-0641"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.04054.x"},{"key":"e_1_2_7_6_1","volume-title":"Medicaid Coverage of Medications to Reverse Opioid Overdose and Treat Alcohol and Opioid Use Disorders. 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