{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:28:54Z","timestamp":1777422534606,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Enteroviral meningitis is a common cause of meningitis in children which requires only supportive care.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>To evaluate the impact of implementing an in\u2010hospital enteroviral polymerase chain reaction (EVPCR) testing protocol on the clinical management of children with meningitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN:<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>POPULATION:<\/jats:title><jats:p>Children &lt;19 years old with meningitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>INTERVENTION:<\/jats:title><jats:p>EVPCR testing differed by time period: send\u2010out testing protocol from July 1, 2006\u2013June 23, 2008 (pre\u2010period) versus in\u2010house testing protocol from June 24, 2008\u2013June 30, 2010 (post\u2010period).<\/jats:p><\/jats:sec><jats:sec><jats:title>MEASUREMENTS:<\/jats:title><jats:p>Test turnaround time, test utilization, length of stay, and duration of parenteral antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of the 441 study patients, 216 (49%) presented during the post\u2010period. Median age was 2.9 months (interquartile range, 1.5\u201396 months). Test turnaround time decreased with the in\u2010house test (53 hours pre vs 13 hours post, <jats:italic>P<\/jats:italic> &lt; 0.001), and test utilization increased (28% pre vs 62% post, <jats:italic>P<\/jats:italic> &lt; 0.001). Among children with a positive EVPCR test, both length of stay (44 hours pre vs 28 hours post, <jats:italic>P<\/jats:italic> = 0.005) and duration of parenteral antibiotics (48 hours pre vs 36 hours post, <jats:italic>P<\/jats:italic> = 0.04) decreased in the post\u2010period. No change in either of these outcomes was observed in children with meningitis and a negative EVPCR test.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION:<\/jats:title><jats:p>In\u2010house EVPCR testing reduced test turnaround time, increased test utilization, and reduced both length of stay and duration of parenteral antibiotics for children with a positive result. Clinicians caring for children with meningitis should have access to in\u2010hospital EVPCR testing. <jats:italic>Journal of Hospital Medicine<\/jats:italic> 2012; \u00a9 2012 Society of Hospital Medicine<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhm.1947","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T14:06:02Z","timestamp":1337177162000},"page":"517-520","source":"Crossref","is-referenced-by-count":18,"title":["Impact of in\u2010hospital enteroviral polymerase chain reaction testing on the clinical management of children with meningitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Todd W.","family":"Lyons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"McAdam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keri A.","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Monuteaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise E.","family":"Nigrovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.971"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)80064-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/656919"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200204000-00005"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0252"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31817e519b"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01718-06"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199908000-00018"},{"key":"e_1_2_7_10_2","volume-title":"SPSS for Windows [computer program]. 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