{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:13:48Z","timestamp":1788941628651,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23 AI099082"],"award-info":[{"award-number":["K23 AI099082"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Among diabetics, complicated skin infections may involve gram\u2010negative pathogens; however, the microbiology of cellulitis and cutaneous abscess is not well established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To compare the microbiology and prescribing patterns between diabetics and nondiabetics hospitalized for cellulitis or abscess.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Secondary analysis of 2 published retrospective cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING\/PATIENTS<\/jats:title>\n                    <jats:p>Adults hospitalized for cellulitis or abscess, excluding infected ulcers or deep tissue infections, at 7 academic and community facilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Microbiological findings and antibiotic use were compared among diabetics and nondiabetics. Multivariable logistic regression was performed to identify factors associated with exposure to broad gram\u2010negative therapy, defined as receipt of at least 2 calendar days of \u03b2\u2010lactamase inhibitors, second\u2010 to fifth\u2010generation cephalosporins, fluoroquinolones, carbapenems, tigecycline, aminoglycosides, or colistin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of 770 total patients with cellulitis or abscess, 167 (22%) had diabetes mellitus. Among the 38% of cases with a positive culture, an aerobic gram\u2010positive organism was isolated in 90% of diabetics and 92% of nondiabetics (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.59); aerobic gram\u2010negative organisms were isolated in 7% and 12%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.28). Overall, diabetics were more likely than nondiabetics to be exposed to broad gram\u2010negative therapy (54% vs 44% of cases,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). By logistic regression, diabetes mellitus was independently associated with exposure to broad gram\u2010negative therapy (odds ratio: 1.66, 95% confidence interval: 1.15\u20102.40).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      In cases of cellulitis or abscess associated with a positive culture, gram\u2010negative pathogens were not more common among diabetics compared with nondiabetics. However, diabetics were overall more likely to be exposed to broad gram\u2010negative therapy suggesting this prescribing practice may not be not warranted.\n                      <jats:italic>Journal of Hospital Medicine<\/jats:italic>\n                      2014;9:788\u2013794. \u00a9 2014 Society of Hospital Medicine\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhm.2267","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T01:54:25Z","timestamp":1412042065000},"page":"788-794","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of the microbiology and antibiotic treatment among diabetic and nondiabetic patients hospitalized for cellulitis or cutaneous abscess"],"prefix":"10.1002","volume":"9","author":[{"given":"Timothy C.","family":"Jenkins","sequence":"first","affiliation":[{"name":"Department of Medicine Denver Health Denver Colorado"},{"name":"Division of Infectious Diseases Denver Health Denver Colorado"},{"name":"Department of Medicine University of Colorado School of Medicine Aurora Colorado"},{"name":"Division of Infectious Diseases University of Colorado School of Medicine Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan C.","family":"Knepper","sequence":"additional","affiliation":[{"name":"Department of Patient Safety and Quality Denver Health Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jason Moore","sequence":"additional","affiliation":[{"name":"Department of Trauma and Critical Care Services Vail Valley Medical Center Vail Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla C.","family":"Saveli","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine Aurora Colorado"},{"name":"Division of Infectious Diseases University of Colorado School of Medicine Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean W.","family":"Pawlowski","sequence":"additional","affiliation":[{"name":"Colorado Infectious Disease Associates Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Perlman","sequence":"additional","affiliation":[{"name":"Department of Medicine Porter Adventist Medical Center Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"McCollister","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Colorado School of Medicine Aurora Colorado"},{"name":"Division of Infectious Diseases University of Colorado School of Medicine Aurora Colorado"},{"name":"Department of Medicine Denver Veterans Affairs Medical Center Denver Colorado"},{"name":"Division of Infectious Diseases Denver Veterans Affairs Medical Center Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Burman","sequence":"additional","affiliation":[{"name":"Department of Medicine Denver Health Denver Colorado"},{"name":"Division of Infectious Diseases Denver Health Denver Colorado"},{"name":"Department of Medicine University of Colorado School of Medicine Aurora Colorado"},{"name":"Division of Infectious Diseases University of Colorado School of Medicine Aurora Colorado"},{"name":"Denver Public Health Denver Health Denver 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