{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:23:20Z","timestamp":1761578600494,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Moderate alcohol consumption has been associated with lower risk of coronary heart disease death, but heavy alcohol consumption may increase risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>We sought to determine the association of alcohol\u2010related diagnoses with in\u2010hospital mortality in patients with acute myocardial infarction (AMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN\/SETTING\/PATIENTS<\/jats:title><jats:p>Discharge data collected from all admissions recorded in the Nationwide Inpatient Sample (NIS) database from 2011. A cross\u2010sectional analysis was performed using regression methods appropriate for the NIS sample design.<\/jats:p><\/jats:sec><jats:sec><jats:title>MEASURES<\/jats:title><jats:p>The outcome measures were in\u2010hospital mortality, length of stay, and cardiac procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>AMI accounted for 610,963 (1.9%) of adult in\u2010patient admissions, with an in\u2010hospital mortality rate of 5.3%. Alcohol\u2010related diagnoses were associated with increased mortality in AMI patients after controlling for factors associated with alcoholism including age, sex, liver disease, hypertension, diabetes, renal failure, peripheral vascular disease, arrhythmias, drug abuse, gastrointestinal bleed, and smoking (adjusted odds ratio [OR]: 1.5, 95% confidence interval [CI]: 1.2\u20101.7, <jats:italic>P<\/jats:italic> &lt; 0.001). This association was significant in both ST\u2010elevation myocardial infarction patients (adjusted OR: 1.7, 95% CI: 1.4\u20102.2, <jats:italic>P<\/jats:italic> &lt; 0.001) and non\u2013ST\u2010elevation myocardial infarction patients (adjusted OR: 1.3, 95% CI: 1.0\u20101.7, <jats:italic>P<\/jats:italic> = 0.025). Chronic alcohol\u2010related diagnoses were significantly associated with death, but acute alcohol effects (as estimated by withdrawal and intoxication) were not associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Chronic alcohol\u2010related diagnoses were associated with a modest increase in the risk for death in individuals presenting with AMI. This risk was not accounted for by common alcohol\u2010related comorbidities. As a component of global efforts to limit hospital deaths from AMI, future research should identify the factors underlying this association. <jats:italic>Journal of Hospital Medicine<\/jats:italic> 2016;11:563\u2013567. \u00a9 2016 Society of Hospital Medicine<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhm.2584","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T11:39:22Z","timestamp":1459769962000},"page":"563-567","source":"Crossref","is-referenced-by-count":7,"title":["Alcohol\u2010related diagnoses and increased mortality in acute myocardial infarction patients: An analysis of the nationwide inpatient sample"],"prefix":"10.1002","volume":"11","author":[{"given":"Siva Harsha","family":"Yedlapati","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine University at Buffalo, State University of New York Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Mendu","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine University at Buffalo, State University of New York Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott H.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine University at Buffalo, State University of New York Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.951015056.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820a55f5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.22.2437"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.887513"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.574749"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.339"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.15.1965"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5568"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01886.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0127-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.11.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.4.394"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.173419"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/136.7.819"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7088.1159"},{"volume-title":"Healthcare Cost and Utilization Project","year":"2011","author":"HCUP Nationwide Inpatient Sample","key":"e_1_2_7_19_1"},{"key":"e_1_2_7_20_1","unstructured":"HCUP Clinical Classifications Software for Services and Procedures.Healthcare Cost and Utilization Project. Rockville MD: Agency for Healthcare Research and Quality; 2008. Available at:http:\/\/www.hcup\u2010us.ahrq.gov\/toolssoftware\/ccs_svcsproc\/ccssvcproc.jsp. Accessed May 10th 2014."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90492-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.68.11.443"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.05.035"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.9.944"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007627"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000227"},{"issue":"5","key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/oxfordjournals.aje.a113464","article-title":"Drinking habits and coronary heart disease: the Yugoslavia cardiovascular disease study","volume":"116","author":"Kozarevic D","year":"1982","journal-title":"Am J Epidemiol."}],"container-title":["Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjhm.2584","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhm.2584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:00:29Z","timestamp":1760623229000},"score":1,"resource":{"primary":{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/10.1002\/jhm.2584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,4]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/jhm.2584"],"URL":"https:\/\/doi.org\/10.1002\/jhm.2584","archive":["Portico"],"relation":{},"ISSN":["1553-5592","1553-5606"],"issn-type":[{"type":"print","value":"1553-5592"},{"type":"electronic","value":"1553-5606"}],"subject":[],"published":{"date-parts":[[2016,4,4]]}}}