{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:42:56Z","timestamp":1785393776994,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T00:00:00Z","timestamp":1209081600000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BACKGROUND\/OBJECTIVE:<\/jats:p><jats:p>Systematic data are limited on the etiology and prognosis of unselected patients with obstructive jaundice (OJ). We aimed to review the clinical features, etiology, and prognosis of patients with OJ.<\/jats:p><jats:p>METHODS:<\/jats:p><jats:p>All adult patients with bilirubin \u2265 5.85 mg\/dL (100 \u03bcmol\/L) at a university hospital in Sweden in 2003\u20132004 were identified. Medical records from patients with OJ were reviewed.<\/jats:p><jats:p>RESULTS:<\/jats:p><jats:p>Seven hundred and forty\u2010nine patients were identified, of whom 241 (32%) had OJ (median age 71 years, 129 women). No one was lost to follow\u2010up. The biliary obstruction of 154 patients (64%) was a result of a malignancy: 69 patients (46%) had pancreatic cancer, 44 (29%) had cholangiocarcinoma (CC), 5 (3%) had papilla vateri cancers, and 36 patients (23%) had other malignancies. Of the 87 patients with a benign obstruction, 57 (65%) had choledocholithiasis, 7 (8%) had biliary strictures, 6% had PSC, and the obstruction of 16 patients (20.7%) had other causes. A total of 115 of the 242 patients (48%) had abdominal pain associated with jaundice, whereas 52% had painless jaundice. Thirty\u2010four percent of patients with a malignant obstruction had abdominal pain versus 71% of patients with a benign obstruction (<jats:italic>P<\/jats:italic> &lt; .05). At the end of follow\u2010up, only 5% (8 patients) with a malignant obstruction were alive versus 78% with a benign obstruction.<\/jats:p><jats:p>CONCLUSIONS:<\/jats:p><jats:p>Obstructive jaundice was the cause of the severe jaundice of one third of patients. Most cases of OJ were a result of a malignancy, which carried a very poor prognosis, with a 2\u2010year mortality rate of 95%. Journal of Hospital Medicine 2008;3:117\u2013123. \u00a9 2008 Society of Hospital Medicine.<\/jats:p>","DOI":"10.1002\/jhm.272","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T14:26:26Z","timestamp":1209133586000},"page":"117-123","source":"Crossref","is-referenced-by-count":29,"title":["Fate of patients with obstructive jaundice"],"prefix":"10.1002","volume":"3","author":[{"given":"Einar","family":"Bj\u00f6rnsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Borkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Kilander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.409"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000492"},{"key":"e_1_2_5_4_2","first-page":"5.1","volume-title":"Comprehensive Clinical Hepatology","author":"Lidofsky SD","year":"2000"},{"key":"e_1_2_5_5_2","first-page":"271","volume-title":"Examination of an adolescent or an adult patient with jaundice. 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