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Using the Pediatric Health Information System database, we sought to describe use and clinical outcomes of children hospitalized with complicated pneumonia who received empiric antibiotic regimens with and without methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) coverage. We evaluated empiric antibiotic selection on Day 0\u20131, grouping based on use of an antibiotic with or without MRSA coverage. We used generalized linear mixed effects models to examine the association of MRSA coverage and outcomes. Across 46 children's hospitals, 71.5% of children (<jats:italic>N<\/jats:italic>\u2009=\u20091279) received an empiric antibiotic regimen with MRSA coverage. In adjusted analyses, length of stay, need for repeat pleural drainage procedures, 7\u2010day emergency department revisits and 7\u2010day readmissions were similar between groups. Future prospective studies examining the need for MRSA coverage may assist in refining national treatment guidelines for complicated pneumonia in children.<\/jats:p>","DOI":"10.1002\/jhm.2736","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T09:19:24Z","timestamp":1641287964000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inpatient outcomes for children receiving empiric methicillin\u2010resistant <i>Staphylococcus aureus<\/i> coverage for complicated pneumonia"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-7721","authenticated-orcid":false,"given":"Jessica L.","family":"Markham","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Mercy Kansas City University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"},{"name":"The University of Kansas School of Medicine Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Hackman","sequence":"additional","affiliation":[{"name":"Department of Graduate Medical Education, Children's Mercy Kansas City University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-5887","authenticated-orcid":false,"given":"Matt","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Mercy Kansas City University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"},{"name":"Children's Hospital Association Lenexa Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaina","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Children's Mercy Kansas City University of Missouri\u2010Kansas City School of Pharmacy Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-8949","authenticated-orcid":false,"given":"Jennifer L.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Mercy Kansas City University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2017.11.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922815589917"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2020-001800"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir531"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"LiuC BayerA CosgroveSE et alClinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin\u2010resistantStaphylococcus aureusinfections in adults and children. 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