{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T21:44:24Z","timestamp":1776203064183,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T00:00:00Z","timestamp":1209081600000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>BACKGROUND:<\/jats:p>\n                  <jats:p>Dexmedetomidine is a potentially useful sedative for hospitalized children, but there is little published data regarding its safety, dosage, or efficacy.<\/jats:p>\n                  <jats:p>OBJECTIVE:<\/jats:p>\n                  <jats:p>To report our experience with dexmedetomidine for the sedation of hospitalized children.<\/jats:p>\n                  <jats:p>DESIGN:<\/jats:p>\n                  <jats:p>Retrospective case series.<\/jats:p>\n                  <jats:p>SETTING:<\/jats:p>\n                  <jats:p>Pediatric ICU of a university\u2010affiliated children's hospital.<\/jats:p>\n                  <jats:p>PATIENTS:<\/jats:p>\n                  <jats:p>We retrospectively examined data from the medical records of all children who received dexmedetomidine for sedation between December 2003 and October 2005.<\/jats:p>\n                  <jats:p>INTERVENTION:<\/jats:p>\n                  <jats:p>None.<\/jats:p>\n                  <jats:p>RESULTS:<\/jats:p>\n                  <jats:p>Dexmedetomidine was administered 74 times to 60 children (median age 1.5 years, range 0.1\u201317.2 years). The most common indications for ICU admission were respiratory distress\/failure (53%), status\u2013postcorrective cardiac surgery (19%), and other postoperative patients (18%). In 53% of cases dexmedetomidine was used to supplement ongoing sedation judged inadequatem and in 41% of cases it was used as a bridge to extubation while other sedatives were weaned or discontinued. Among all the children, the median dose to maintain adequate sedation was 0.7 \u03bcg\/kg per hour (range 0.2\u20132.5 \u03bcg\/kg per hour), with a median duration of therapy of 23 hours (range 3\u2013451 hours). Most children (80%) experienced no adverse effects from the sedation, with hypotension (9%), hypertension (8%), and bradycardia (3%) the most common adverse events. For 93% of children who experienced a side effect, it resolved either without treatment or by withholding the infusion.<\/jats:p>\n                  <jats:p>CONCLUSIONS:<\/jats:p>\n                  <jats:p>In this cohort of children hospitalized in the ICU, dexmedetomidine appeared to be effective and to have few adverse effects. Dexmedetomidine may have a potentially useful role to play in sedating hospitalized children. Journal of Hospital Medicine 2008;3:142\u2013147. \u00a9 2008 Society of Hospital Medicine.<\/jats:p>","DOI":"10.1002\/jhm.282","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T14:18:32Z","timestamp":1209133112000},"page":"142-147","source":"Crossref","is-referenced-by-count":36,"title":["Use of dexmedetomidine for sedation of children hospitalized in the intensive care unit"],"prefix":"10.1002","volume":"3","author":[{"given":"Christopher L.","family":"Carroll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel 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