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Newly available drugs include those in the echinocandin class, including caspofungin, micafungin, and anidulafungin, as well as the newer generation triazoles, voriconazole and posaconazole. Ordering of these agents is variably restricted, depending on a given institution's policies, and all are costly. In this review we examine the available evidence and outline the role of newer antifungal medications in several common and\/or important situations, including invasive and mucocutaneous <jats:italic>Candida<\/jats:italic> infection, febrile neutropenia, invasive aspergillosis, zygomycosis, and endemic mycoses. 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