{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:35:58Z","timestamp":1760661358614,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Historically, the milk\u2010alkali syndrome developed as an adverse reaction to the Sippy regimen of milk, cream and alkaline powders as treatment for peptic ulcer disease. The classic description includes hypercalcemia, metabolic alkalosis, and renal failure. Over the past 20 years, milk\u2010alkali syndrome has had a resurgence, as consumption of supplements containing calcium has increased. A 46\u2010year\u2010old man presented to the emergency department after outpatient labs to evaluate his fatigue. He was found to have acute renal failure and hypercalcemia (total serum calcium was 15.9 mg\/dL). Subsequent laboratory evaluation excluded both hyperparathyroidism and malignancy as causes. A detailed history led to the diagnosis of milk\u2010alkali syndrome. With hydration and cessation of calcium carbonate ingestion, his renal function and serum calcium levels returned to normal. Physicians should have a high index of suspicion for milk\u2010alkali syndrome in patients with hypercalcemia. Milk\u2010alkali syndrome is no longer a merely a historical curiosity; it is currently the third most common cause of hypercalcemia. Journal of Hospital Medicine 2010;5:E18\u2013E20. \u00a9 2010 Society of Hospital Medicine.<\/jats:p>","DOI":"10.1002\/jhm.579","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T16:01:42Z","timestamp":1264521702000},"source":"Crossref","is-referenced-by-count":7,"title":["Hypercalcemia and acute renal failure in milk\u2010alkali syndrome: A case report"],"prefix":"10.1002","volume":"5","author":[{"given":"Kimberly","family":"Ulett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Centor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.250.16.2192"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200605000-00001"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02383.x"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199503000-00004"},{"issue":"8","key":"e_1_2_3_6_2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1001\/archinte.1993.00410080065011","article-title":"The milk\u2010alkali syndrome. A reversible form of acute renal failure","volume":"153","author":"Abreo K","year":"1993","journal-title":"Arch Intern Med."},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-4-200808190-00007"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553290"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198304000-00009"}],"container-title":["Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjhm.579","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhm.579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhm.579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhm.579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:59:08Z","timestamp":1760641148000},"score":1,"resource":{"primary":{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/10.1002\/jhm.579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,26]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/jhm.579"],"URL":"https:\/\/doi.org\/10.1002\/jhm.579","archive":["Portico"],"relation":{},"ISSN":["1553-5592","1553-5606"],"issn-type":[{"type":"print","value":"1553-5592"},{"type":"electronic","value":"1553-5606"}],"subject":[],"published":{"date-parts":[[2010,1,26]]}}}