{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:59:33Z","timestamp":1770145173647,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["shmpublications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Concerns about contrast\u2010associated acute kidney injury (CA\u2010AKI) may lead to individuals not undergoing necessary contrast\u2010enhanced imaging. Effective risk stratification plays a crucial role in patient management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a prediction model combining the effects of multiple risk factors to predict risk of CA\u2010AKI for individuals undergoing intravenous contrast\u2010enhanced computed tomography (CECT) imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective cohort study, 906 inpatient and outpatient adults who underwent CECT imaging in two tertiary centers, St. Luke's Medical Center\u2014Quezon City and St. Luke's Medical Center\u2014Global City, located in Manila, Philippines, were included. Multivariate logistic regression was used to identify independent predictors for CA\u2010AKI. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009\u2264\u20090.05 was considered significant. Based on the odds ratio, five parameters were identified and included in the model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of CA\u2010AKI was 10.38%. A significant association was found between CA\u2010AKI with in\u2010hospital mortality (odds ratio [OR]: 4.23, confidence interval [CI]: 2.59\u20136.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and AKI requiring renal replacement therapy (OR: 3.57, CI: 1.94\u20136.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) among admitted patients. Multivariate analysis included reduced estimated glomerular filtration rate (OR\u2009=\u200917.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), acute heart failure (OR\u2009=\u20099.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), hypotension (OR\u2009=\u20095.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), anemia (OR\u2009=\u20094.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and use of nephrotoxic antibiotics (OR\u2009=\u20095.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) in the final prediction model. The prediction model had fair predictive power (area under the curve\u2009=\u20090.737) and good calibration (Hosmer\u2013Lemeshow\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.418).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This prediction model, incorporating clinical and laboratory parameters, provides a practical tool for estimating CA\u2010AKI risk with fair discrimination and good internal calibration. It may support informed decision\u2010making regarding the risks and benefits of intravenous CECT. External validation is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhm.70136","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T17:39:45Z","timestamp":1755538785000},"page":"142-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and internal validation of a prediction model for intravenous contrast\u2010associated acute kidney injury"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-1798","authenticated-orcid":false,"given":"Kristel K.","family":"Tanhui\u2010Manzana","sequence":"first","affiliation":[{"name":"Center for Renal Diseases, St. Luke's Medical Center Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7225-9315","authenticated-orcid":false,"given":"Arlene C.","family":"Crisostomo","sequence":"additional","affiliation":[{"name":"Center for Renal Diseases, St. Luke's Medical Center Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5721-0533","authenticated-orcid":false,"given":"Irene S.","family":"Bandong","sequence":"additional","affiliation":[{"name":"Department of Radiology St. Luke's Medical Center Quezon City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vimar A.","family":"Luz","sequence":"additional","affiliation":[{"name":"Center for Renal Diseases St. Luke's Medical Center Global City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4562-9402","authenticated-orcid":false,"given":"Bryian P.","family":"Paner","sequence":"additional","affiliation":[{"name":"Center for Renal Diseases St. Luke's Medical Center Global City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7103-072X","authenticated-orcid":false,"given":"Jenn D. 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