{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:05:29Z","timestamp":1787313929580,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL173694"],"award-info":[{"award-number":["K23HL173694"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL163692"],"award-info":[{"award-number":["R01HL163692"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["shmpublications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Community\u2010acquired pneumonia (CAP) is a frequent and costly cause of pediatric emergency department (ED) visits and hospitalizations. Previous prognostic tools for CAP are limited by small samples, single\u2010center or retrospective designs, lack of generalizability to ED settings, lack of biomarkers, or limited objective data. To overcome these limitations, we will derive and externally validate a prediction rule for pediatric CAP severity in a large, multicenter prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective cohort study of children 3 months to 18 years old with CAP who present to EDs within the Pediatric Emergency Care Applied Research Network. Enrollment began 8\/2023 and will end 7\/2027. We exclude children with recent hospitalizations and chronic conditions (e.g., immunosuppression). A follow\u2010up survey and record review is completed 8\u201315 days after the visit. Blood and nasal specimens are obtained to evaluate the role of C\u2010reactive protein, procalcitonin, proadrenomedullin, and viral detection in severity prediction. The primary outcome is severity (three\u2010tiered outcome of mild, moderate, or severe CAP) within 7 days of ED presentation. Model derivation will occur in ~4000 children from 7 EDs over 2 years. External validation will occur in a distinct cohort of at least 2000 children from 7 different EDs. Penalized regression, recursive partitioning, and machine learning will be used in model development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>At study completion, we will have a validated CAP severity prediction rule well\u2010positioned for implementation and further evaluation. We will also understand the role of specific biomarkers in predicting outcomes in children with CAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhm.70220","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:10:39Z","timestamp":1763791839000},"page":"590-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Derivation and validation of the Pediatric Community\u2010Acquired Pneumonia Severity (PedCAPS) score: A prospective cohort study"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-2605","authenticated-orcid":false,"given":"Todd A.","family":"Florin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Emergency Medicine Northwestern University Feinberg School of Medicine, Ann and Robert H. Lurie Children\u2032s Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Reeder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilliam","family":"Ambroggio","sequence":"additional","affiliation":[{"name":"Sections of Emergency Medicine and Hospital Medicine, Children\u2032s Hospital Colorado, Department of Pediatrics University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Ruddy","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Cincinnati Children\u2032s Hospital Medical Center, Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-7000","authenticated-orcid":false,"given":"Samir S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Divisions of Hospital Medicine and Infectious Diseases, Cincinnati Children\u2032s Hospital Medical Center, Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Cator","sequence":"additional","affiliation":[{"name":"Departments of Emergency Medicine and Pediatrics University of Michigan Medical School and Children\u2032s Emergency Services, C.S. Mott Children\u2032s Hospital Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Lipshaw","sequence":"additional","affiliation":[{"name":"Departments of Emergency Medicine and Pediatrics University of Michigan Medical School and Children\u2032s Emergency Services, C.S. Mott Children\u2032s Hospital Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A.","family":"Capraro","sequence":"additional","affiliation":[{"name":"Departments of Emergency Medicine and Pediatrics Hasbro Children\u2032s Hospital\/Warren Alpert Medical School of Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura F.","family":"Sartori","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Children\u2032s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Y.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Pediatric Emergency Medicine, Department of Pediatrics University of Texas Southwestern Medical Center Dallas Texas 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Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris A.","family":"Rees","sequence":"additional","affiliation":[{"name":"Division of Pediatric Emergency Medicine Emory University School of Medicine Atlanta Georgia USA"},{"name":"Department of Emergency Medicine Children\u2032s Healthcare of Atlanta Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9947-588X","authenticated-orcid":false,"given":"Son H.","family":"McLaren","sequence":"additional","affiliation":[{"name":"Division of Pediatric Emergency Medicine, Department of Emergency Medicine Columbia University Vagelos College of Physicians and Surgeons New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar R.","family":"Lubell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Emergency Medicine, Department of Emergency Medicine Columbia University Vagelos College of 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