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Of these patients, approximately 90% tolerate penicillin when re\u2010challenged, potentially due to misattribution of nonallergic rash as hypersensitivity or outgrowing the index reaction. Patients with penicillin allergy labels are more likely to receive less effective therapy, develop antibiotic resistance, incur higher healthcare costs, and have poorer outcomes. Although cephalosporins are recommended for most patients with a reported or confirmed penicillin allergy, de\u2010labeling and removing penicillin allergies represent an impactful antimicrobial stewardship activity. A recently developed scoring tool (PEN\u2010FAST) identifies those at low risk for a recurrent reaction and is less cumbersome than traditional testing methods.<\/jats:p>","DOI":"10.1002\/jhm.70254","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:15:45Z","timestamp":1767863745000},"page":"1165-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical progress note: De\u2010labeling penicillin allergies"],"prefix":"10.1002","volume":"21","author":[{"given":"Carter","family":"Groch","sequence":"first","affiliation":[{"name":"Methodist Richardson Medical Center Department of Pharmacy Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephy","family":"George","sequence":"additional","affiliation":[{"name":"Texas Health Presbyterian Hospital Dallas Department of Pharmacy Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Giddings","sequence":"additional","affiliation":[{"name":"University Health System Department of Pharmacotherapy and Pharmacy Services San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Faust","sequence":"additional","affiliation":[{"name":"Texas Health Presbyterian Hospital Dallas Department of Pharmacy Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Feldman","sequence":"additional","affiliation":[{"name":"Preston Hollow Allergy Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2024.68"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.2227"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2023.1101321"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.08.028"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8367"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S242061"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy7030103"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-1-200407060-00010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.04.058"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab544"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.05.037"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12008"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0403"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.1572"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.2986"}],"container-title":["Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhm.70254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhm.70254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhm.70254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:08:27Z","timestamp":1791194907000},"score":1,"resource":{"primary":{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/10.1002\/jhm.70254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jhm.70254"],"URL":"https:\/\/doi.org\/10.1002\/jhm.70254","archive":["Portico"],"relation":{},"ISSN":["1553-5592","1553-5606"],"issn-type":[{"value":"1553-5592","type":"print"},{"value":"1553-5606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"2025-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}