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Despite FDA approval for only select neuropathic conditions, most use is for off\u2010label pain indications. Randomized trials show minimal or clinically insignificant benefit for most off\u2010label pain syndromes. In contrast, gabapentinoids are associated with sedation, falls, delirium, respiratory depression, misuse, and hospitalization, especially with opioids or renal impairment. Given limited efficacy and harms, they should not routinely substitute for opioids. Clinicians should reassess indications, deprescribe when appropriate, and prioritize nonpharmacologic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhm.70286","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:34:15Z","timestamp":1771223655000},"page":"670-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Things We Do for No Reason\u2122: Prescribing gabapentinoids for pain"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-5860","authenticated-orcid":false,"given":"Niti G.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goese","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Belknap","sequence":"additional","affiliation":[{"name":"Independent Scholar Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Madeira","sequence":"additional","affiliation":[{"name":"Department of Medicine Lewis Katz School of Medicine at Temple University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Barsuk","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Statista. 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