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Current guidelines recommend direct oral anticoagulants and low\u2010molecular\u2010weight heparin (LMWH) as first\u2010line therapy for most patients based on superior efficacy and ease of use. Compared with unfractionated heparin (UFH), LMWH provides more predictable anticoagulation, achieves therapeutic levels rapidly with weight\u2010based dosing, and requires minimal laboratory monitoring. Randomized trials and observational studies demonstrate that LMWH is associated with lower rates of recurrent venous thromboembolism (VTE), bleeding, and heparin\u2010induced thrombocytopenia. 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