{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:12:07Z","timestamp":1785499927992,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T00:00:00Z","timestamp":1278979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Cerebrospinal fluid (CSF) protein values decline over the first few months of life as the infant's blood\u2010CSF barrier matures. However, published studies differ in the reported rate, timing, and magnitude of this decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>To quantify the age\u2010related changes in CSF protein concentration and to determine accurate, age\u2010specific reference values for neonates and young infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN, SETTING AND PATIENTS:<\/jats:title><jats:p>This cross\u2010sectional study included infants age 56 days or younger who had a lumbar puncture performed in the emergency department of an urban tertiary care children's hospital between January 1, 2005 and June 30, 2007. Infants with conditions associated with elevated CSF protein concentrations, including traumatic lumbar puncture and bacterial or viral meningitis, were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of 1064 infants undergoing lumbar puncture, 375 (35%) met inclusion criteria. The median CSF protein value was 58 mg\/dL (interquartile range: 48\u201372 mg\/dL). In linear regression, the CSF protein concentration decreased 6.8% (95% confidence interval [CI], 5.4%\u20108.1%; <jats:italic>P<\/jats:italic> &lt; 0.001) with each 1 week increase in age. The 95th percentile values were 115 mg\/dL for infants \u226428 days and 89 mg\/dL for infants 29\u201356 days. The 95th percentile values by age category were as follows: ages 0\u201314 days, 132 mg\/dL; ages 15\u201328 days, 100 mg\/dL; ages 29\u201342 days, 89 mg\/dL; and ages 43\u201356 days, 83 mg\/dL.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>We quantify the age\u2010related decline in CSF protein concentration among infants 56 days of age and younger and provide age\u2010specific reference values. The values reported here represent the largest series to\u2010date for this age group. Journal of Hospital Medicine 2011. \u00a9 2010 Society of Hospital Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhm.711","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T10:46:55Z","timestamp":1279018015000},"page":"22-27","source":"Crossref","is-referenced-by-count":56,"title":["Age\u2010specific reference values for cerebrospinal fluid protein concentration in neonates and young infants"],"prefix":"10.1002","volume":"6","author":[{"given":"Samir S.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ebberson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Kestenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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