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The evidence base for pain management in SCD is lacking. We therefore offer some evidence and our informed opinion to answer frequently asked questions (FAQs) about pain management by hospitalists caring for adults with SCD. The most common questions center around defining a crisis; selecting and managing opioids; distinguishing between opioid tolerance, physical dependence, and addiction or misuse; determining appropriateness of discharge; and avoiding lengthy or recurrent hospitalizations. Journal of Hospital Medicine 2011. \u00a9 2011 Society of Hospital Medicine.<\/jats:p>","DOI":"10.1002\/jhm.933","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T18:37:28Z","timestamp":1308076648000},"page":"297-303","source":"Crossref","is-referenced-by-count":29,"title":["Frequently asked questions by hospitalists managing pain in adults with sickle cell disease"],"prefix":"10.1002","volume":"6","author":[{"given":"Wally R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanetta B.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Hassell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07330-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.409"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904013401307"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871529X10909040271"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/03630260802625709"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.87.8.1317"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050460"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb021260"},{"key":"e_1_2_6_11_2","volume-title":"The Advanced Medical Home: A Patient\u2010Centered, Physician\u2010Guided Model of Health Care","year":"2006"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1070-3241(01)27007-2"},{"key":"e_1_2_6_13_2","unstructured":"Definition of Disease Prevalence for Therapies Qualifying Under the Orphan Drug Act. 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