{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:38:39Z","timestamp":1778031519958,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI095014 02S1"],"award-info":[{"award-number":["R01 AI095014 02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern AIDS Soc"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Pregnant women newly diagnosed with HIV<\/jats:styled-content> during pregnancy are often lost to follow up and their adherence rates drop after delivery. We quantified changes in priorities related to isoniazid preventive therapy (IPT<\/jats:styled-content>) and antiretroviral therapy (ART<\/jats:styled-content>) among pregnant women living with HIV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We enrolled pregnant women recently diagnosed with HIV<\/jats:styled-content> from 14 primary health clinics during pregnancy and followed them after delivery in Matlosana, South Africa. Best\u2013worst scaling (BWS<\/jats:styled-content>) was used to determine the women's priorities out of 11 attributes related to preventive therapy in the ante\u2010 versus postpartum periods. Aggregate BWS<\/jats:styled-content> scores were calculated based on the frequency with which participants selected each attribute as the best or worst among five options (across multiple choice sets). Individual BWS<\/jats:styled-content> scores were also calculated and rescaled from 0 (always selected as worst) to 10 (always selected as best), and changes in BWS<\/jats:styled-content> scores in the ante\u2010 versus postpartum periods were compared, using a paired t<\/jats:italic>\u2010test. Factors associated with the changes in BWS<\/jats:styled-content> scores were examined in multiple linear regressions. Spearman's rho was used to compare the ranking of attributes.<\/jats:p><\/jats:sec>Results<\/jats:title>Out of a total of 204 participants, 154 (75.5%) completed the survey in the postpartum at the median 15 (IQR<\/jats:styled-content>: 11 to 27) weeks after delivery. Trust in healthcare providers was most highly prioritized both in the ante\u2010 (individual BWS<\/jats:styled-content> Score<\/jats:italic>\u00a0=\u00a07.34, SE<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.13)<\/jats:italic> and postpartum periods (BWS<\/jats:styled-content><\/jats:italic>\u00a0=\u00a07.21<\/jats:italic>\u00a0\u00b1\u00a00.11<\/jats:italic>), followed by living a long life (BWS<\/jats:styled-content><\/jats:italic>\u00a0=\u00a06.77<\/jats:italic>\u00a0\u00b1\u00a00.09<\/jats:italic> in the ante\u2010 vs. BWS<\/jats:styled-content><\/jats:italic>\u00a0=\u00a06.86<\/jats:italic>\u00a0\u00b1\u00a00.10<\/jats:italic> in the postpartum)<\/jats:italic>. Prevention for infants\u2019 health was more prioritized in the post\u2010 (BWS<\/jats:styled-content><\/jats:italic>\u00a0=\u00a06.54<\/jats:italic>\u00a0\u00b1\u00a00.09<\/jats:italic>) versus antepartum periods (BWS<\/jats:styled-content><\/jats:italic>\u00a0=\u00a06.11<\/jats:italic>\u00a0\u00b1\u00a00.10<\/jats:italic>) (p<\/jats:italic>\u00a0=\u00a00.05). This change was associated with IPT<\/jats:styled-content> initiation at enrolment (regression coefficient\u00a0=\u00a00.78\u00a0\u00b1\u00a00.33, p<\/jats:italic>\u00a0=\u00a00.001). Difficulty in daily pill\u2010uptake was significantly more prioritized in the postpartum (BWS<\/jats:styled-content><\/jats:italic>\u00a0=\u00a05.03<\/jats:italic>\u00a0\u00b1\u00a00.11<\/jats:italic>) than in the antepartum (BWS<\/jats:styled-content><\/jats:italic>\u00a0=\u00a04.43<\/jats:italic>\u00a0\u00b1\u00a00.10<\/jats:italic>) (p<\/jats:italic>\u00a0<\u00a00.01). Transportation cost and worry about side effects of pills were least prioritized. Overall ranking of attributes was similar in both time periods (spearman's rho\u00a0=\u00a00.90).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Comprehensive interventions to build trust in healthcare providers and support adherence may increase uptake of preventive therapy. Counselling needs to emphasize medication benefits for both maternal and infant health among HIV<\/jats:styled-content>\u2010positive pregnant women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25143","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T13:52:38Z","timestamp":1530712358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Maternal priorities for preventive therapy among HIV<\/scp>\u2010positive pregnant women before and after delivery in South Africa: a\u00a0best\u2013worst scaling survey"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-1555","authenticated-orcid":false,"given":"Hae\u2010Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Africa Health Research Institute Durban KwaZulu\u2010Natal South Africa"},{"name":"School of Nursing & Public Health University of KwaZulu\u2010Natal Durban KwaZulu\u2010Natal South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W","family":"Dowdy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil A","family":"Martinson","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit University of Witwatersrand Johannesburg South Africa"},{"name":"Center for Tuberculosis Research Johns Hopkins University Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"E Golub","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Center for Tuberculosis Research Johns Hopkins University Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F P","family":"Bridges","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Department of Health Policy and Management Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Department of Health Behavior and Society Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen F","family":"Hanrahan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Global Tuberculosis Report 2017. 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