{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:31:20Z","timestamp":1781562680411,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council (NHMRC) Program","award":["568971"],"award-info":[{"award-number":["568971"]}]},{"name":"Australian NHMRC Early Career Fellowships","award":["1104781"],"award-info":[{"award-number":["1104781"]}]},{"name":"Australian NHMRC Early Career Fellowships","award":["1091226"],"award-info":[{"award-number":["1091226"]}]},{"name":"Australian NHMRC Early Career Fellowships","award":["1091536"],"award-info":[{"award-number":["1091536"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern AIDS Soc"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Men who have sex with men (MSM<\/jats:styled-content>) living with HIV<\/jats:styled-content> have a high risk of anal cancer, which is often detected at late stages, when morbidity and mortality are high. The objective of this study was to describe the feasibility and challenges to incorporating regular digital anorectal examination (DARE<\/jats:styled-content>) into routine HIV<\/jats:styled-content> care for MSM<\/jats:styled-content> living with HIV<\/jats:styled-content>, from the perspective of patients, physicians and the health service.<\/jats:p><\/jats:sec>Methods<\/jats:title>In 2014, we recruited 327 MSM<\/jats:styled-content> living with HIV<\/jats:styled-content>, aged 35 and above from one major sexual health centre (n\u00a0=\u00a0187), two high HIV<\/jats:styled-content> caseload general practices (n\u00a0=\u00a0118) and one tertiary hospital (n\u00a0=\u00a022) in Melbourne, Australia. Men were followed up for two years and DARE<\/jats:styled-content> was recommended at baseline, year 1 and year 2. Data were collected regarding patient and physician experience, and health service use. An ordered logit model was used to assess the relationship between sociodemographic factors and the number of DARE<\/jats:styled-content>s performed.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age of men was 51 (SD<\/jats:styled-content>\u00a0\u00b1\u00a09) years, 69% were Australian born, 32% current smokers, and mean CD<\/jats:styled-content>4 was 630 (SD<\/jats:styled-content>\u00a0\u00b1\u00a0265) cells per mm3<\/jats:sup>, with no significant differences between clinical sites. Overall, 232 (71%) men received all three DARE<\/jats:styled-content>s, 71 (22%) received two DARE<\/jats:styled-content>s, and 24 (7%) had one DARE<\/jats:styled-content>. Adverse outcomes were rarely reported: anal pain (1.2% of total DARE<\/jats:styled-content>s), bleeding (0.8%) and not feeling in control of their body during the examination (1.6%). Of 862 DARE<\/jats:styled-content>s performed, 33 (3.8%) examinations resulted in a referral to a colorectal surgeon. One Stage 1 anal cancer was detected.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Incorporation of an early anal cancer detection programme into routine HIV<\/jats:styled-content> clinical care for MSM<\/jats:styled-content> living with HIV<\/jats:styled-content> showed high patient acceptability, uncommon adverse outcomes and specialist referral patterns similar to other cancer screening programmes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25192","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T12:58:34Z","timestamp":1544014714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Incorporating digital anorectal examinations for anal cancer screening into routine HIV<\/scp> care for men who have sex with men living with HIV<\/scp>: a prospective cohort study"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-7403","authenticated-orcid":false,"given":"Jason J","family":"Ong","sequence":"first","affiliation":[{"name":"Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"London School of Hygiene and Tropical Medicine London UK"},{"name":"Melbourne Sexual Health Centre Alfred Health Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Walker","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre Alfred Health Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Grulich","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hoy","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital and Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-4848","authenticated-orcid":false,"given":"Tim RH","family":"Read","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre Alfred Health Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre Alfred Health Carlton Victoria 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J","family":"Templeton","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales Sydney New South Wales Australia"},{"name":"RPA Sexual Health Sydney Local Health District Sydney Medical School The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Hocking","sequence":"additional","affiliation":[{"name":"Melbourne School of Population and Global Health University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beng","family":"Eu","sequence":"additional","affiliation":[{"name":"Prahran Market Clinic Prahran Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bian Kiem","family":"Tee","sequence":"additional","affiliation":[{"name":"The Centre Clinic Victorian AIDS Council St Kilda Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P 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