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However, data on recent causes of death in the Asia\u2010Pacific region are limited. Hence, we analysed and compared AIDS\u2010related and non\u2010AIDS\u2013related mortality in high\u2010 and low\u2010income settings in the region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from the TREAT Asia HIV Observational Database (TAHOD) and Australian HIV Observational Database (AHOD) receiving cART between 1999 and 2017 were included. Causes of death verification were based on review of the standardized Cause of Death (CoDe) form designed by the D:A:D group. Cohorts were grouped as AHOD (all high\u2010income sites), TAHOD\u2010high (high\/upper\u2010middle income countries) and TAHOD\u2010low (lower\u2010middle income countries). TAHOD sites were split into high\/upper\u2010middle income and lower\u2010middle income country settings based on World Bank classifications. Competing risk regression was used to analyse factors associated with AIDS and non\u2010AIDS\u2013related mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 10,386 patients, 522 died; 187 from AIDS\u2010related and 335 from non\u2010AIDS\u2013related causes. The overall incidence rate of deaths during follow\u2010up was 0.28 per 100 person\u2010years (\/100 PYS) for AIDS and 0.51\/100 PYS for non\u2010AIDS. Analysis indicated that the incidence rate of non\u2010AIDS mortality decreased from 0.78\/100 PYS to 0.37\/100 PYS from year groups 2003 to 2007 to 2013 to 2017 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Similarly, incidence rates of AIDS\u2010related deaths decreased from 0.51\/100 PYS to 0.09\/100 PYS from year groups 2003 to 2007 to 2013 to 2017 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). More recent years of follow\u2010up were associated with reduced hazard for non\u2010AIDS mortality (2008 to 2012: aSHR (adjusted sub\u2010hazard ratio) 0.72, 95% confidence interval (CI) 0.54 to 0.96, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027; 2013 to 2017: aSHR 0.64, 95% CI 0.47 to 0.87, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) compared to years 2003 to 2007. The AHOD cohort had almost twice the hazard of non\u2010AIDS mortality compared to TAHOD\u2010low (lower\u2010middle income sites) (aSHR 1.72, 95% CI, 1.20 to 2.46, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003); there were no differences between cohorts for AIDS\u2010related mortality (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.834).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AIDS and non\u2010AIDS\u2013related mortality rates have decreased over the past years in the Asia\u2010Pacific region. There is a greater risk for non\u2010AIDS\u2013associated deaths in the AHOD cohort compared to lower\u2010middle income settings in TAHOD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25219","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:17:06Z","timestamp":1546985826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Trends in mortality among ART\u2010treated HIV\u2010infected adults in the Asia\u2010Pacific region between 1999 and 2017: results from the TREAT Asia HIV Observational Database (TAHOD) and Australian HIV Observational Database (AHOD) of IeDEA Asia\u2010Pacific"],"prefix":"10.1002","volume":"22","author":[{"given":"In Young","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju South Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanushi","family":"Rupasinghe","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Woolley","sequence":"additional","affiliation":[{"name":"Monash Infectious Diseases Monash Health and Monash University Clayton Vic. Australia"},{"name":"Department of Infectious Diseases The Alfred Hospital and Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C","family":"O'Connor","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney Sydney NSW Australia"},{"name":"Sexual Health Service Sydney Local Health District Camperdown NSW Australia"},{"name":"Central Clinical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-1822","authenticated-orcid":false,"given":"Michelle","family":"Giles","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Alfred Hospital and Monash University Melbourne Vic. 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