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However, the effects of age\u2010associated comorbidities on the treatment outcomes of combination antiretroviral therapy (<jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content>) are not well known. In this study, we investigated the effects of age\u2010associated comorbidities on therapeutic outcomes of <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive adults in Asian countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients enrolled in the <jats:styled-content style=\"fixed-case\">TREAT<\/jats:styled-content> Asia <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> Observational Database cohort and on <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> for more than six months were analysed. Comorbidities included hypertension, diabetes, dyslipidaemia and impaired renal function. Treatment outcomes of patients <jats:bold>\u2265<\/jats:bold>50\u00a0years of age with comorbidities were compared with those &lt;50\u00a0years and those <jats:bold>\u2265<\/jats:bold>50\u00a0years without comorbidities. We analysed 5411 patients with virological failure and 5621 with immunologic failure. Our failure outcomes were defined to be in\u2010line with the World Health Organization 2016 guidelines. Cox regression analysis was used to analyse time to first virological and immunological failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of virologic failure was 7.72\/100 person\u2010years. Virological failure was less likely in patients with better adherence and higher <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 count at <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> initiation. Those acquiring <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> through intravenous drug use were more likely to have virological failure compared to those infected through heterosexual contact. On univariate analysis, patients aged &lt;50\u00a0years without comorbidities were more likely to experience virological failure than those aged \u226550\u00a0years with comorbidities (hazard ratio 1.75, 95% confidence interval (CI) 1.31 to 2.33, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). However, the multivariate model showed that age\u2010related comorbidities were not significant factors for virological failure (hazard ratio 1.31, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.98 to 1.74, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.07). There were 391 immunological failures, with an incidence of 2.75\/100 person\u2010years. On multivariate analysis, those aged &lt;50\u00a0years without comorbidities (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.025) and age &lt;50\u00a0years with comorbidities (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) were less likely to develop immunological failure compared to those aged \u226550\u00a0years with comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our Asia regional cohort, age\u2010associated comorbidities did not affect virologic outcomes of <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content>. Among those with comorbidities, patients &lt;50\u00a0years old showed a better <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25228","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T04:39:19Z","timestamp":1551155959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The influence of age\u2010associated comorbidities on responses to combination antiretroviral therapy in older people living with <scp>HIV<\/scp>"],"prefix":"10.1002","volume":"22","author":[{"given":"Mi Young","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea"},{"name":"AIDS Research Institute Yonsei University College of Medicine Seoul South Korea"},{"name":"Department of Internal Medicine Seoul Medical Center Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awachana","family":"Jiamsakul","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwimon","family":"Khusuwan","sequence":"additional","affiliation":[{"name":"Chiangrai Prachanukroh Hospital Chiang Rai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vohith","family":"Khol","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology &amp; 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