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We sought to determine the rate of adverse events (AE<\/jats:styled-content>s) and discontinuations among Thais treated during acute HIV<\/jats:styled-content> infection (AHI<\/jats:styled-content>) and switched to DTG<\/jats:styled-content>\u2010based regimens.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thai participants in the SEARCH<\/jats:styled-content>010\/RV<\/jats:styled-content>254 cohort who initiated ART<\/jats:styled-content> during AHI<\/jats:styled-content> and switched to DTG<\/jats:styled-content> for at least 48\u00a0weeks were prospectively observed and included in the analysis. Rates and characteristics of DTG<\/jats:styled-content>\u2010related AE<\/jats:styled-content>s and discontinuations were described.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 313 Thai participants were included in the analysis. The median age was 29\u00a0years, 96% were male, 64% had a Bachelor's degree or higher and 16% had a body mass index (BMI<\/jats:styled-content>) <18.5\u00a0kg\/m2<\/jats:sup>. Participants were on ART<\/jats:styled-content> for a median of 124\u00a0weeks before switching to DTG<\/jats:styled-content>. The median (IQR<\/jats:styled-content>) body weight increased from 63 (56 to 70) kg before to 65 (58 to 73) kg (p<\/jats:italic>\u00a0<\u00a00.0001) after 48\u00a0weeks of DTG<\/jats:styled-content>. Forty\u2010nine (16%) developed DTG<\/jats:styled-content>\u2010related AE<\/jats:styled-content>s, corresponding to an incidence of 16.6 per 100 person\u2010years. Neuropsychiatric symptoms were most frequently encountered (n\u00a0=\u00a025, 8%), followed by laboratory abnormalities (n\u00a0=\u00a016, 5%). Six (2%) discontinued DTG<\/jats:styled-content>, corresponding to an incidence of 2.4 per 100 person\u2010years. All discontinuations were due to increased liver enzymes in the presence of hepatitis C virus coinfection. In the multivariate analysis, incident hepatitis C virus infection was the only risk factor for discontinuing DTG<\/jats:styled-content> (hazard ratio 59.4, 95% CI<\/jats:styled-content> 8.5 to 297.9, p<\/jats:italic>\u00a0<\u00a00.0001). Neither low BMI<\/jats:styled-content> nor concurrent abacavir therapy was associated with discontinuation.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>DTG<\/jats:styled-content> was well tolerated with few discontinuations in this cohort of young men. Incident hepatitis C virus infection was a driver of liver\u2010related AE<\/jats:styled-content>s leading to discontinuations. In populations at risk, regular testing for hepatitis C virus during ART<\/jats:styled-content> is recommended to anticipate possible AE<\/jats:styled-content>s, guide management and improve safety.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25324","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T13:24:50Z","timestamp":1562851490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Switch to dolutegravir is well tolerated in Thais with HIV<\/scp> infection"],"prefix":"10.1002","volume":"22","author":[{"given":"Orlanda Q","family":"Goh","sequence":"first","affiliation":[{"name":"SEARCH The Thai Red Cross AIDS Research Centre Bangkok Thailand"},{"name":"Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"},{"name":"Duke\u2010National University of Singapore Medical School Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donn J","family":"Colby","sequence":"additional","affiliation":[{"name":"SEARCH The Thai Red Cross AIDS Research Centre Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suteeraporn","family":"Pinyakorn","sequence":"additional","affiliation":[{"name":"The Henry M. 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