{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:00Z","timestamp":1753869420731,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005027","name":"Belgisch Ontwikkelingsagentschap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern AIDS Soc"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Following the introduction of option B+ in 2013, and with the perspective of eliminating mother\u2010to\u2010child transmission of HIV by 2025, Cambodia has implemented an integrated active case management (IACM) approach since 2014 to improve the notification and follow\u2010up of all HIV\u2010infected cases including pregnant women, and to ensure access to and use of the full prevention of mother\u2010to\u2010child transmission (PMTCT) service package by HIV\u2010infected pregnant women and their HIV\u2010exposed infants. This study aimed to analyse PMTCT cascade data in 15 operational districts (ODs) implementing the IACM approach in Cambodia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed PMTCT cohort data from 15 ODs implementing IACM approach between 1 January 2014 and 31 December 2016. We measured key indicators along the PMTCT cascade and compared them to available (cross\u2010sectional) PMTCT indicators during the 2011 to 2013 period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the period 2014 to 2016, among 938 identified HIV\u2010infected pregnant women, 308 (32.8%) were tested HIV positive during their pregnancy, 9 (1.0%) during labour, while the remaining 621 (66.2%) were women on antiretroviral therapy (ART) who became pregnant. During the study period, 867 (92.4%) of the 938 women received ART during pregnancy and labour. Subsequently, 456 (85.6%) of the 533 HEI born and alive during the study period received 6\u2010week antiretroviral (ARV) prophylaxis, 390 (76.6%) and 396 (77.8%) of the 509 infants aged six weeks or older received cotrimoxazole prophylaxis and HIV\u2010DNA PCR test respectively. Among the 396 HEI who received HIV\u2010DNA PCR test, 7 (1.8%) were found HIV positive. The comparison with cross\u2010sectional PMTCT indicator obtained during the previous 2011 to 2013 period in the same 15 ODs, showed a significant increase in ARV uptake among HIV\u2010infected pregnant women (from 72.3% to 92.4%), in cotrimoxazole uptake (from 41.6% to 73.2%), and in HIV\u2010DNA PCR testing coverage among HEI (from 41.2% to 74.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The implementation of option B+ and IACM may have contributed to the improvement of the PMTCT cascade in Cambodia. However, some gaps in accessing PMTCT services along the HIV cascade persist and need to be addressed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25388","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T06:14:22Z","timestamp":1571638462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Access to prevention of mother\u2010to\u2010child transmission of <scp>HIV<\/scp> along <scp>HIV<\/scp> services cascade through integrated active case management in 15 operational districts in Cambodia"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-2176","authenticated-orcid":false,"given":"Sovannarith","family":"Samreth","sequence":"first","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology and STD Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vannak","family":"Keo","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology and STD Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romaing","family":"Tep","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology and STD Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angheng","family":"Ke","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology and STD Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vichea","family":"Ouk","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology and STD Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora","family":"Ngauv","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology and STD Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sovatha","family":"Mam","sequence":"additional","affiliation":[{"name":"University of Health Science Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Ferradini","sequence":"additional","affiliation":[{"name":"FHI 360 Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penh S","family":"Ly","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology and STD Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhi V","family":"Mean","sequence":"additional","affiliation":[{"name":"University of Health Science Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Delvaux","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505256"},{"key":"e_1_2_10_3_1","unstructured":"UNAIDS.Global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive.Geneva:Joint United Nations Programme on HIV\/AIDS.2011."},{"key":"e_1_2_10_4_1","unstructured":"WHO.Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach.Geneva:World Health Organization;2013."},{"key":"e_1_2_10_5_1","unstructured":"UNAIDS.On the fast track to an AIDS\u2010free generation. 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