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We therefore studied the motives for choosing for, switching between, and stopping daily or event\u2010driven PrEP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used data (August 2015\u2010June 2017) from the prospective, longitudinal, open\u2010label Amsterdam PrEP<\/jats:styled-content> demonstration study, in which daily (dPrEP<\/jats:styled-content>) and event\u2010driven PrEP<\/jats:styled-content> (edPrEP<\/jats:styled-content>) were offered to 374 HIV<\/jats:styled-content>\u2010negative MSM<\/jats:styled-content> and two transgender persons. Participants self\u2010selected the preferred PrEP<\/jats:styled-content>\u2010regimen at baseline and could switch regimens at three\u2010monthly follow\u2010up visits. We measured motives for choosing PrEP<\/jats:styled-content>\u2010regimen at baseline and for switching and stopping PrEP<\/jats:styled-content> at follow\u2010up visits. Open\u2010 and closed\u2010end items were combined and qualitatively analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>Choices of PrEP<\/jats:styled-content>\u2010regimens were determined by personal and contextual factors, involving the perceived self\u2010efficacy concerning adherence, the risk\u2010context, and the anticipated impact of PrEP<\/jats:styled-content> on physical and sexual wellbeing. dPrEP<\/jats:styled-content> was preferred because of the anticipated better adherence and the fear of side\u2010effects relating to edPrEP<\/jats:styled-content> re\u2010initiations. Moreover, dPrEP<\/jats:styled-content> was perceived to be more effective than edPrEP<\/jats:styled-content>. Motives to choose edPrEP<\/jats:styled-content> were the expected physical burden of dPrEP<\/jats:styled-content>, anticipated side\u2010effects of dPrEP<\/jats:styled-content>, and fear to forget daily doses. Regarding the risk\u2010context: dPrEP<\/jats:styled-content> was preferred for unplanned and\/or frequent sex, while edPrEP<\/jats:styled-content> was chosen when risk was predictable and\/or less frequent. While some chose for dPrEP<\/jats:styled-content> to gain more sexual freedom, others chose for edPrEP<\/jats:styled-content> to minimize sexual risk episodes. Changes in the above factors, such as changing risk patterns, changing relationships or changing physical conditions, resulted in switching regimens. Choices to stop PrEP<\/jats:styled-content> were related to lower sexual risk, adherence issues and side\u2010effects.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The great diversity of motives illustrates the importance of offering a choice of PrEP<\/jats:styled-content>\u2010regimens. In counselling of MSM<\/jats:styled-content> starting PrEP<\/jats:styled-content>, choices for PrEP<\/jats:styled-content>\u2010regimens may be addressed as a continuum of flexible and changeable options over time. This may help individuals choose the PrEP<\/jats:styled-content>\u2010regimen that best fits their current sexual context, priorities and personal capabilities and therefore will be more easily adhered to.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25389","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T06:24:33Z","timestamp":1571120673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Motives for choosing, switching and stopping daily or event\u2010driven pre\u2010exposure prophylaxis \u2013 a qualitative analysis"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1647-8485","authenticated-orcid":false,"given":"Hanne ML","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention Public Health Service of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne W","family":"Eekman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention Public Health Service of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel CA","family":"Achterbergh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Public Health Service of Amsterdam STI Outpatient Clinic Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten F","family":"Schim van der Loeff","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention Public Health Service of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Infectious Diseases Amsterdam Institute for Infection and Immunity (AI&II) Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Prins","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention Public Health Service of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Infectious Diseases Amsterdam Institute for Infection and Immunity (AI&II) Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-547X","authenticated-orcid":false,"given":"Henry JC","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Public Health Service of Amsterdam STI Outpatient Clinic Amsterdam the Netherlands"},{"name":"Department of Dermatology Amsterdam Institute for Infection and Immunity (AI&II) Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0512-2109","authenticated-orcid":false,"given":"Elske","family":"Hoornenborg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention Public Health Service of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Infectious Diseases Public Health Service of Amsterdam STI Outpatient Clinic Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udi","family":"Davidovich","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention Public Health Service of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Infectious Diseases Amsterdam Institute for Infection and Immunity (AI&II) Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Consortium (H\u2010TEAM)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001145"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00056-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"e_1_2_9_6_1","unstructured":"European Medicines Agency (EMA).First medicine for HIV pre\u2010exposure prophylaxis recommended for approval in the EU [press release].London United Kingdom:EMA;2016."},{"key":"e_1_2_9_7_1","unstructured":"World Health Organization (WHO).Consolidated guidelines on HIV prevention diagnosis treatment and care for key populations 2016 update. 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