{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:07:31Z","timestamp":1792613251231,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern AIDS Soc"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pre\u2010Exposure Prophylaxis (PrEP) is highly effective in reducing the risk for HIV infection among men who have sex with men (MSM) and may have an important impact in slowing down the HIV epidemic. Concerns remain however about low adherence, increased risk behaviour and reduced condom use when using PrEP. The aim of this study was to assess these factors prospectively among MSM using daily and event\u2010driven PrEP in Belgium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An open\u2010label prospective cohort study was conducted from October 2017 to May 2018 at the Institute of Tropical Medicine, in Antwerp, Belgium. At enrolment, MSM at high risk for HIV chose between daily or event\u2010driven PrEP. They were allowed to switch regimens or stop taking PrEP at each of their tri\u2010monthly visits. Data were collected on an electronic case report form, web\u2010based diary and self\u2010administered questionnaire. Screening for HIV and other Sexually Transmitted Infections (STIs) was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred MSM were followed up for a total duration of 318 person\u2010years. At month 18, 75.4% of the participants were on daily and 24.6% were on event\u2010driven PrEP. The mean proportion of covered sex acts by PrEP for the complete follow\u2010up period was 91.5% for all participants, 96.5% for daily and 67.0% for event\u2010driven PrEP use. The number of casual and anonymous sex partners was significantly higher for daily users, as compared with event\u2010driven users, but did not change over time. In contrast, the mean proportion of condomless receptive anal intercourse with casual and anonymous partners increased significantly during follow\u2010up, for both daily and event\u2010driven use (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001 for all 4 trends). No new HIV infection was diagnosed during follow\u2010up. The incidence of bacterial STIs was 75.4 per 100 person\u2010years (95% CI 63.8 to 89.1). We did not detect a significant change in\n                      <jats:italic>N. gonorrhoeae<\/jats:italic>\n                      \/\n                      <jats:italic>C. trachomatis<\/jats:italic>\n                      incidence over time. The incidence of hepatitis C was 2.9 per 100 person\u2010years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PrEP is an effective and well adopted HIV prevention tool for MSM in Belgium. Participants adapted daily and event\u2010driven regimens to their own needs and were able to adapt their PrEP adherence to risk exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.25407","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T03:16:55Z","timestamp":1572405415000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Daily and event\u2010driven pre\u2010exposure prophylaxis for men who have sex with men in Belgium: results of a prospective cohort measuring adherence, sexual behaviour and STI incidence"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-4372","authenticated-orcid":false,"given":"Bea","family":"Vuylsteke","sequence":"first","affiliation":[{"name":"Department of Public Health Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thijs","family":"Reyniers","sequence":"additional","affiliation":[{"name":"Department of Public Health Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irith","family":"De Baetselier","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"N\u00f6stlinger","sequence":"additional","affiliation":[{"name":"Department of Public Health Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Crucitti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozefien","family":"Buyze","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Kenyon","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristien","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Laga","sequence":"additional","affiliation":[{"name":"Department of Public Health Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00056-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30215-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70847-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix593"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.12.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000647"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000220"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-015-1238-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30088-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001766"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000213"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1086"},{"key":"e_1_2_11_15_1","first-page":"909","article-title":"Will risk compensation accompany pre\u2010exposure prophylaxis for HIV?","volume":"16","author":"Blumenthal J","year":"2014","journal-title":"Virtual Mentor"},{"issue":"5","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/cid\/ciy182","article-title":"Effects of pre\u2010exposure prophylaxis for the prevention of HIV infection on sexual risk behavior in men who have sex with men: a systematic review and meta\u2010analysis","volume":"67","author":"Traeger MW","journal-title":"Clin Infect Dis"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208107"},{"key":"e_1_2_11_18_1","unstructured":"European Centre for Disease Prevention and Control\/WHO Regional Office for Europe.HIV\/AIDS surveillance in Europe 2018\u20102017 data. 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