{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:06:48Z","timestamp":1768320408916,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["14697"],"award-info":[{"award-number":["14697"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern AIDS Soc"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite the advent of HIV cure\u2010related clinical trials (HCRCT) for people living with HIV (PLWH), the risks and uncertainty involved raise ethical issues. Although research has provided insights into the levers and barriers to PLWH and physicians' participation in these trials, no information exists about stakeholders' preferences for HCRCT attributes, about the different ways PLWH and physicians value future HCRCT, or about how personal characteristics affect these preferences. The results from the present study will inform researchers' decisions about the most suitable HCRCT strategies to implement, and help them ensure ethical recruitment and well\u2010designed informed consent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between October 2016 and March 2017, a discrete choice experiment was conducted among 195 virally controlled PLWH and 160 physicians from 24 French HIV centres. Profiles within each group, based on individual characteristics, were obtained using hierarchical clustering. Trade\u2010offs between five HCRCT attributes (trial duration, consultation frequency, moderate (digestive disorders, flu\u2010type syndrome, fatigue) and severe (allergy, infections, risk of cancer) side effects (SE), outcomes) and utilities associated with four HCRCT candidates (latency reactivation, immunotherapy, gene therapy and a combination of latency reactivation and immunotherapy), were estimated using a mixed logit model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apart from severe SE \u2013 the most decisive attribute in both groups \u2013 PLWH and physicians made different trade\u2010offs between HCRCT attributes, the latter being more concerned about outcomes, the former about the burden of participation (consultation frequency and moderate SE). These different trades\u2010offs resulted in differences in preferences regarding the four candidate HCRCT. PLWH significantly preferred immunotherapy, whereas physicians preferred immunotherapy and combined therapy. Despite the heterogeneity of characteristics within the PLWH and physician profiles, results show some homogeneity in trade\u2010offs and utilities regarding HCRCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe SE, not outcomes, was the most decisive attribute determining future HCRCT participation. Particular attention should be paid to providing clear information, in particular on severe SE, to potential participants. Immunotherapy would appear to be the best HCRCT candidate for both PLWH and physicians. However, if the risk of cancer could be avoided, gene therapy would become the preferred strategy for the latter and the second choice for the former.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25443","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T09:31:22Z","timestamp":1582191082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Differences in HIV cure clinical trial preferences of French people living with HIV and physicians in the ANRS\u2010APSEC study: a discrete choice experiment"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-9617","authenticated-orcid":false,"given":"Christel","family":"Protiere","sequence":"first","affiliation":[{"name":"INSERM, IRD, SESSTIM, Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de l'Information M\u00e9dicale Aix Marseille Univ Marseille France"},{"name":"ORS PACA Observatoire r\u00e9gional de la sant\u00e9 Provence\u2010Alpes\u2010C\u00f4te d'Azur Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Arnold","sequence":"additional","affiliation":[{"name":"Informing Change Berkeley CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"INSERM, IRD, SESSTIM, Sciences Economiques &amp; 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