{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:38:17Z","timestamp":1792791497296,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007729","name":"Ministerie van Buitenlandse Zaken","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. Intern. AIDS Soc."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>WHO\u2019s 2019 report on HIV drug resistance (HIVDR) documents a high prevalence of pretreatment drug resistance (PDR) among populations initiating first\u2010line antiretroviral therapy (ART) in low\u2010 and middle\u2010income countries (LMIC). However, systematic evidence on the prevalence of PDR among key populations remains limited. We performed a systematic review to characterize levels of PDR in key population groups and compared them to levels of PDR in the \u201cgeneral population\u201d across different geographical regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten electronic databases were searched for papers published until February 2019 that included predefined search terms. We included studies that reported the number of successfully tested genotypes and the number of genotypes with drug resistance mutations among antiretroviral therapy treatment na\u00efve people, recently infected people, or people initiating first\u2010line ART from key populations. To assess the prevalence of PDR for each key population, we pooled estimates using random\u2010effects meta\u2010analysis of proportions. Where possible, we computed the differences in the odds of PDR (any, and by drug class) present in each key population compared to the \u201cgeneral population\u201d. The I<jats:sup>2<\/jats:sup> statistic (a measure of heterogeneity between studies) is reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>A total of 332 datasets (from 218 studies) and 63,111 people with successful HIVDR genotyping were included in the analysis. The pooled prevalence estimate of any PDR was high among men who have sex with men (13.0%, 95% CI 11.0 to 14.0%, I<jats:sup>2<\/jats:sup>\u00a0=\u00a093.19), sex workers (17.0%, 95% CI 6.0 \u2013 32.0, I<jats:sup>2<\/jats:sup>\u00a0=\u00a087.31%) and people in prisons (18.0%, 95% CI 11.0 to 25.0, I<jats:sup>2<\/jats:sup>\u00a0=\u00a070.18%), but less so among people who inject drugs (7.0%, 95% CI 5.0 to 10.0, I<jats:sup>2<\/jats:sup>\u00a0=\u00a090.23). Overall, men who have sex with men were more likely to carry any PDR compared to the \u201cgeneral population,\u201d a finding which was statistically significant (odds ratio (OR) 1.28, 95% CI 1.13 \u2013 1.46, I<jats:sup>2<\/jats:sup> 48.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High prevalence of PDR found in key populations highlights the need to increase access to effective first\u2010line HIV treatment. The low prevalence of nucleotide reverse transcriptase inhibitor (NRTI) PDR suggests that current WHO recommendations for pre\u2010exposure prophylaxis (PrEP) regimens will remain effective and can be scaled up to prevent new HIV infections in high\u2010risk groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25656","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T07:10:34Z","timestamp":1608880234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Prevalence of pretreatment HIV drug resistance in key populations: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-6059","authenticated-orcid":false,"given":"Virginia","family":"Macdonald","sequence":"first","affiliation":[{"name":"Department of HIV, Hepatitis, and Sexually Transmitted Diseases World Health Organization Geneva 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Mathers","sequence":"additional","affiliation":[{"name":"Department of HIV, Hepatitis, and Sexually Transmitted Diseases World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Jay","sequence":"additional","affiliation":[{"name":"Department of HIV, Hepatitis, and Sexually Transmitted Diseases World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Baggaley","sequence":"additional","affiliation":[{"name":"Department of HIV, Hepatitis, and Sexually Transmitted Diseases World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Verster","sequence":"additional","affiliation":[{"name":"Department of HIV, Hepatitis, and Sexually Transmitted Diseases World Health Organization Geneva 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