{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:46Z","timestamp":1786978066625,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011893","name":"Pan American Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["K23AI1120875"],"award-info":[{"award-number":["K23AI1120875"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI069923"],"award-info":[{"award-number":["U01AI069923"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. Intern. AIDS Soc."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Kaposi\u2019s sarcoma (KS) remains the most frequent malignancy in persons living with HIV (PWH) in Latin America. We examined KS trends and outcomes from Latin American clinical sites in the era of increased access to antiretroviral therapy (ART).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cohorts in Brazil, Peru, Mexico, Honduras, Argentina and Chile contributed clinical data of PWH \u226516\u00a0years old from 2000 to 2017, excluding patients with KS diagnosed before clinic enrolment. We compared KS incidence over time using multivariable incidence rate ratios. Predictors of KS before\/at or after ART initiation and of mortality after KS were examined using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 25\u00a0981 PWH, 481 had incident KS, including 200 ART\u2010na\u00efve and 281 ART\u2010treated patients. From 2000 to 2017, the incidence of KS decreased from 55.1 to 3.0 per 1000 person\u2010years. In models adjusting for CD4 and other factors, the relative risk for KS decreased from 2000 to 2008. Since 2010, the adjusted risk of KS increased in the periods before and \u226490\u00a0days after ART initiation but decreased &gt;90\u00a0days after ART. In addition to low CD4 and male\u2010to\u2010male sex, KS risk after ART was associated with age and history of other AIDS\u2010defining illnesses. Mortality after KS (approximately 25% after five years) was not associated with either year of KS diagnosis nor timing of diagnosis relative to ART initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>KS incidence in Latin America has remained stable in recent years and risk is highest before and shortly after ART initiation. Early diagnosis of HIV and ART initiation remain critical priorities in the region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.25658","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:13:51Z","timestamp":1610064831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antiretroviral therapy and Kaposi\u2019s sarcoma trends and outcomes among adults with HIV in Latin America"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-8173","authenticated-orcid":false,"given":"Jessica L","family":"Castilho","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahra","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy A","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-5155","authenticated-orcid":false,"given":"Beatriz","family":"Grinsztejn","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectiologia Evandro Chagas Fiocruz Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Gotuzzo","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia Instituto de Medicina Tropical Alexander von Humboldt Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-4781","authenticated-orcid":false,"given":"Valeria","family":"Fink","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Hu\u00e9sped Investigaciones Cl\u00ednicas Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Padgett","sequence":"additional","affiliation":[{"name":"Instituto Hondure\u00f1o de Seguridad Social and Hospital Escuela Universitario Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-4734","authenticated-orcid":false,"given":"Pablo F","family":"Belaunzaran\u2010Zamudio","sequence":"additional","affiliation":[{"name":"Deparatmento de Infectologia Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n. Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2587-1123","authenticated-orcid":false,"given":"Brenda","family":"Crabtree\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Deparatmento de Infectologia Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n. Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-2617","authenticated-orcid":false,"given":"Maria Mercedes","family":"Escuder","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State Department of Health Institute of Health S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-0203","authenticated-orcid":false,"given":"Rosa Alencar","family":"Souza","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State Department of Health AIDS Reference and Training Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-161X","authenticated-orcid":false,"given":"Simone B","family":"Tenore","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State Department of Health AIDS Reference and Training Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidnei R","family":"Pimentel","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State Department of Health AIDS Reference and Training Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-2298","authenticated-orcid":false,"given":"Maria Let\u00edcia Rodrigues","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Care and Treatment Clinic of the Partenon Sanatorium Rio Grande do Sul State Department of Health Porto Alegre Brazil"},{"name":"University of Vale do Rio dos Sinos S\u00e3o Leopoldo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-1353","authenticated-orcid":false,"given":"Paulo R","family":"de Alencastro","sequence":"additional","affiliation":[{"name":"Care and Treatment Clinic of the Partenon Sanatorium Rio Grande do Sul State Department of Health Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unai","family":"Tupinanbas","sequence":"additional","affiliation":[{"name":"Medical School Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-6991","authenticated-orcid":false,"given":"Carlos","family":"Brites","sequence":"additional","affiliation":[{"name":"Edgar Santos University Hospital Complex Federal University of Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1062-7179","authenticated-orcid":false,"given":"Estela","family":"Luz","sequence":"additional","affiliation":[{"name":"Edgar Santos University Hospital Complex Federal University of Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Netto","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectiologia Evandro Chagas Fiocruz Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9101-9783","authenticated-orcid":false,"given":"Claudia P","family":"Cortes","sequence":"additional","affiliation":[{"name":"Fundaci\u00f2n Arriaran and University of Chile School of Medicine Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-0597","authenticated-orcid":false,"given":"Alexandre","family":"Grangeiro","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-5992","authenticated-orcid":false,"given":"Bryan E","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C","family":"McGowan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Caribbean, Central, South America network for HIV Epidemiology (CCASAnet)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31820bb1c3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000238411.75324.59"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-10-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix480"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604520"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001394"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.156"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/589865"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064392"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym073"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095673"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001221"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23487"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328317cc2d"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9196-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-018-0188-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.618"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy960"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2652-13-51"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25235"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001397"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.17.4.19490"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20309"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12584"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.75"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25088"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603056"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000993"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2018.0028"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200009000-00009"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31818d5bf8"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.25658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jia2.25658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.25658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:28:07Z","timestamp":1692984487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jia2.25658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jia2.25658"],"URL":"https:\/\/doi.org\/10.1002\/jia2.25658","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25658"}}