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Socio\u2010economic interventions, like livelihood and employability programmes, address HIV vulnerabilities like poverty and gender inequality. We explored the HIV\u2010sensitivity of socio\u2010economic interventions for unemployed and out\u2010of\u2010school young women aged 15 to 30\u00a0years, in East and Southern Africa, a key population for HIV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review using a narrative synthesis method and the Mixed Methods Appraisal Tool for quality appraisal. Interventions of interest were work skills training, microfinance, and employment support. Outcomes of interest were socio\u2010economic outcomes (income, assets, savings, skills, (self\u2010) employment) and HIV\u2010related outcomes (behavioural and biological). We searched published and grey literature (January 2005 to November 2019; English\/French) in MEDLINE, Scopus, Web of Science and websites of relevant international organizations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We screened 3870 titles and abstracts and 188 full\u2010text papers to retain 18 papers, representing 12 projects. Projects offered different combinations of HIV\u2010sensitive social protection programmes, complemented with mentors, safe space and training (HIV, reproductive health and gender training). All 12 projects offered work skills training to improve life and business skills. Six offered formal (<jats:italic>n<\/jats:italic>= 2) or informal (<jats:italic>n<\/jats:italic>= 5) livelihood training. Eleven projects offered microfinance, including microgrants (<jats:italic>n<\/jats:italic>= 7), microcredit (<jats:italic>n<\/jats:italic>= 6) and savings (<jats:italic>n<\/jats:italic>= 4). One project offered employment support in the form of apprenticeships. In general, microgrants, savings, business and life skills contributed improved socio\u2010economic and HIV\u2010related outcomes. Most livelihood training contributed positive socio\u2010economic outcomes, but only two projects showed improved HIV\u2010related outcomes. Microcredit contributed little to either outcome. Programmes were effective when (i) sensitive to beneficiaries' age, needs, interests and economic vulnerability; (ii) adapted to local implementation contexts; and (iii) included life skills. Programme delivery through mentorship and safe space increased social capital and may be critical to improve the HIV\u2010sensitivity of socio\u2010economic programmes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A wide variety of livelihood and employability programmes were leveraged to achieve improved socio\u2010economic and HIV\u2010related outcomes among unemployed and out\u2010of\u2010school young women. To be HIV\u2010sensitive, programmes should be designed around their interests, needs and vulnerability, adapted to local implementation contexts, and include life skills. Employment support received little attention in this literature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25787","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T15:37:52Z","timestamp":1630597072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["HIV\u2010sensitive social protection for vulnerable young women in East and Southern Africa: a systematic review"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-5466","authenticated-orcid":false,"given":"Ran","family":"van der Wal","sequence":"first","affiliation":[{"name":"Department of Family Medicine McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Loutfi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan Nha","family":"Hong","sequence":"additional","affiliation":[{"name":"EPPI\u2010Centre UCL Social Research Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Vedel","sequence":"additional","affiliation":[{"name":"Department of Family Medicine McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cockcroft","sequence":"additional","affiliation":[{"name":"Department of Family Medicine McGill University Montreal Quebec Canada"},{"name":"CIET Trust Gaborone Botswana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Johri","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) Montreal Quebec Canada"},{"name":"D\u00e9partement de gestion d\u2019\u00e9valuation et de politique de sant\u00e9 \u00c9cole de sant\u00e9 publique de l'Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Family Medicine McGill University Montreal Quebec Canada"},{"name":"Centro de Investigaci\u00f3n de Enfermedades Tropicales Universidad Aut\u00f3noma de Guerrero Acapulco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Communities at the Centre.Geneva:UNAIDS;2019."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0268580917693172"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001584"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2010.487314"},{"key":"e_1_2_12_6_1","volume-title":"Addressing the structural drivers of HIV: a strive synthesis","author":"Strive Research Consortium","year":"2019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040260"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000341777.78876.40"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60548-X"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000300533.59483.95"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00087-X"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000341776.71253.04"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60887-9"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000390709.04255.fd"},{"key":"e_1_2_12_15_1","volume-title":"Combination HIV Prevention: Tailoring and Coordinating Biomedial, Behavioral and Structural Strategies to Reduce New HIV Infections","year":"2010"},{"key":"e_1_2_12_16_1","volume-title":"Work and Women's Marriage, Fertility, and Empowerment: Evidence from Textile Mill Employment in India","author":"Sivasankaran A","year":"2014"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10887-009-9039-9"},{"key":"e_1_2_12_18_1","unstructured":"DevereuxS Sabates\u2010WheelerR. 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