{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:32:57Z","timestamp":1792398777104,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Due to the effectiveness of combined antiretroviral therapy and its growing availability worldwide, most people living with HIV (PLHIV) have a near\u2010normal life expectancy. However, PLHIV continue to face various health and social challenges that severely impact their health\u2010related quality\u2010of\u2010life (HRQoL). The UNAIDS Global AIDS Strategy discusses the need to optimize quality\u2010of\u2010life, but no guidance was given regarding which instruments were appropriate measures of HRQoL. This study aimed to review and assess the use of HRQoL instruments for PLHIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a global systematic review and meta\u2010analysis, searching five databases for studies published between January 2010 and February 2021 that assessed HRQoL among PLHIV aged 16 years and over. Multivariable regression analyses were performed to identify factors associated with the choice of HRQoL instruments. We examined the domains covered by each instrument. Random\u2010effects meta\u2010analysis was conducted to explore the average completion rates of HRQoL instruments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and discussion<\/jats:title>\n                    <jats:p>\n                      From 714 publications, we identified 65 different HRQoL instruments. The most commonly used instruments were the World Health Organization Quality\u2010of\u2010Life\u2010 HIV Bref (WHOQOL\u2010HIV BREF)\u201419%, Medical Outcome Survey\u2010HIV (MOS\u2010HIV)\u201417%, Short Form\u201036 (SF\u201036)\u201412%, European Quality\u2010of\u2010Life Instrument\u20105 Dimension (EQ\u20105D)\u201410%, World Health Organization Quality\u2010of\u2010Life Bref (WHOQOL BREF)\u20148%, Short Form\u201012 (SF\u201012)\u20147% and HIV\/AIDS Targeted Quality\u2010of\u2010Life (HAT\u2010QOL)\u20146%. There were greater odds of using HIV\u2010specific instruments for middle\u2010 and low\u2010income countries (than high\u2010income countries), studies in the Americas and Europe (than Africa) and target population of PLHIV only (than both PLHIV and people without HIV). Domains unique to the HIV\u2010specific instruments were worries about death, stigma and HIV disclosure. There were no significant differences in completion rates between different HRQoL instruments. The overall pooled completion rate was 95.9% (95% CI: 94.7\u221297.0,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 99.2%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01); some heterogeneity was explained by country\u2010income level and study type.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A wide range of instruments have been used to assess HRQoL in PLHIV, and the choice of instrument might be based on their different characteristics and reason for application. Although completion rates were high, future studies should explore the feasibility of implementing these instruments and the appropriateness of domains covered by each instrument.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.25902","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T07:09:18Z","timestamp":1649488158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Use of quality\u2010of\u2010life instruments for people living with HIV: a global systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7717-5691","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"He","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Peasgood","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S. G.","family":"Hulse","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Fairley","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4901-0974","authenticated-orcid":false,"given":"Graham","family":"Brown","sequence":"additional","affiliation":[{"name":"Centre for Social Impact University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ofori\u2010Asenso","sequence":"additional","affiliation":[{"name":"Monash Outcomes Research and Health Economics Monash University  Melbourne Victoria Australia"},{"name":"Real World Data Enabling Platform Roche Products Ltd  Welwyn Garden City UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Ong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne Victoria Australia"},{"name":"Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Estimated number of people (all ages) living with HIV","author":"World Health Organization","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327027HC1603_3"},{"key":"e_1_2_10_4_1","volume-title":"90\u201390\u201390: good progress, but the world is off\u2010track for hitting the 2020 targets","author":"The Joint United Nations Programme on HIV\/AIDS (UNAIDS)","year":"2020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545109712456429"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200624080-00003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4137\/HSI.S11093"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17062127"},{"issue":"8","key":"e_1_2_10_9_1","first-page":"889","article-title":"Measuring disease\u2010specific quality of life in clinical trials","volume":"134","author":"Guyatt GH","year":"1986","journal-title":"Can Med Assoc J"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0778-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00984"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545109709355828"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aimed.2017.12.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2020.0028"},{"key":"e_1_2_10_15_1","unstructured":"HigginsJ ThomasJ ChandlerJ CumpstonM LiT PageM et\u00a0al.Cochrane handbook for systematic reviews of interventions version 6.2: Cochrane; 2021 [updated February 2021]. 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