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To bridge the gap in Kenya we: (1) determined the prevalence of CMDs among OALWH on routine HIV care compared to HIV\u2010negative peers; (2) investigated HIV status as an independent predictor of CMDs in older adults; and (3) investigated CMD determinants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study conducted between 2020 and 2021, the prevalence of CMDs and associated determinants were investigated at the Kenyan coast among 440 adults aged \u226550 years (257 OALWH). The Patient Health Questionnaire and Generalized Anxiety Disorder scale were administered alongside measures capturing biopsychosocial information. Logistic regression was used to examine the correlates of CMDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were found in the prevalence of mild depressive symptoms, 23.8% versus 18.2% (<jats:italic>p<\/jats:italic> = 0.16) and mild anxiety symptoms, 11.7% versus 7.2% (<jats:italic>p<\/jats:italic> = 0.12) among OALWH compared to HIV\u2010negative peers, respectively. HIV status was not independently predictive of CMDs. Among OALWH, higher perceived HIV\u2010related stigma, ageism, increasing household HIV burden, loneliness, increasing functional disability, sleeping difficulties, chronic fatigue and advanced age (&gt;70 years) were associated with elevated CMDs. Among HIV\u2010negative older adults, loneliness, increased medication burden and sleeping difficulties were associated with elevated depressive symptoms. Easier access to HIV care was the only factor associated with lower CMDs among OALWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>On the Kenyan coast, the burden of moderate and severe CMDs among older adults is low; however, both OALWH and their HIV\u2010negative peers have a similar relatively high burden of mild depressive and anxiety symptoms. Our results also suggest that determinants of CMDs among OALWH in this setting are predominantly psychosocial factors. These results highlight the need for psychosocial interventions (at the family, community and clinical levels) to mitigate the risks of mild CMDs as they are known to be potentially debilitating.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25977","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T03:40:08Z","timestamp":1664509208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence and factors associated with mild depressive and anxiety symptoms in older adults living with HIV from the Kenyan coast"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-1465","authenticated-orcid":false,"given":"Patrick N.","family":"Mwangala","sequence":"first","affiliation":[{"name":"Centre for Geographic Medicine Research Coast Kenya Medical Research Institute (KEMRI)  Kilifi Kenya"},{"name":"School of Public Health University of the Witwatersrand  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