{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:46Z","timestamp":1786978066577,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sarcopenia is an important clinical syndrome in older people living with HIV (PLWH). With a change to the Asia sarcopenia definition in 2019, we aimed to determine whether health outcomes were associated with different definitions of sarcopenia among Asian PLWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a prospective cross\u2010sectional study enrolling PLWH aged \u226535 years from January 2018 to November 2021. We defined sarcopenia by the Asia Working Group of Sarcopenia (AWGS) criteria in 2014 and 2019. AWGS\u20102014 included low muscle mass plus weak handgrip strength and\/or slow gait speed. AWGS\u20102019 included low muscle mass plus low muscle strength or physical performance, while the presence of all defines severe sarcopenia. We measured appendicular skeletal muscle mass using dual\u2010energy X\u2010ray absorptiometry, handgrip strength, usual gait speed, five\u2010time chair stand test and Short Physical Performance Battery. Correlations between each sarcopenia definition and health\u2010related quality of life (using EQ\u20105D\u20105L and SF\u201036) and functional disability were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and fifty Asian PLWH were enrolled, 132 (88%) were male, mean age was 60\u00b110 years, duration of HIV diagnosis was 13 (IQR 8\u201318) years and current CD4 count was 574 (IQR 362\u2013762) cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      , 67 (45%) had multimorbidity, 64 (43%) had polypharmacy. Prevalence of sarcopenia by AWGS\u20102014, AWGS\u20102019 and severe sarcopenia was 17.3%, 27.3% and 18.0%, respectively. Age, education and polypharmacy were associated with sarcopenia. Sarcopenia (AWGS\u20102014) and severe sarcopenia were associated with mobility, physical functioning and physical component score (SF\u201036). All three criteria were associated with impaired instrumental activities of daily living (IADL). After age and sex adjustment, sarcopenia (AWGS\u20102014) (adjusted odds ratio\/aOR 5.4, 95% confidence interval\/CI 2.0\u201315.1) and severe sarcopenia (aOR 5.1, 95% CI 1.9\u201314.0) were associated with mobility and physical component score (SF\u201036) (\u03b2 coefficients \u20135.3342,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022 and \u20135.412,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019). Sarcopenia (AWGS 2014) (aOR 5.2, 95% CI 1.7\u201316.2), sarcopenia (AWGS\u20102019) (aOR 4.5, 95% CI 1.5\u201313.1) and severe sarcopenia (aOR 3.5, 95% CI 1.1\u201310.9) were associated with impaired IADL in fully adjusted models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a sample of Asian PLWH, 17.3%, 27.3% and 18.0% had sarcopenia as defined by AWGS\u20102014, AWGS\u20102019 and severe sarcopenia, respectively. Sarcopenia by AWGS\u20102014 and severe sarcopenia correlated with parameters of poor health outcomes, while sarcopenia by AWGS\u20102019 correlated with functional disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.25988","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:39:55Z","timestamp":1664494795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sarcopenia in people living with HIV in Hong Kong: which definition correlates with health outcomes?"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-952X","authenticated-orcid":false,"given":"Fion Wing Lam","family":"Luk","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics Prince of Wales Hospital  Sha Tin Hong 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Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Ma Liu Shui Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Chi Yui","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Ma Liu Shui Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Ma Liu Shui Hong 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