{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:54:59Z","timestamp":1793660099524,"version":"4.5.1"},"reference-count":41,"publisher":"Wiley","issue":"S5","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Transgender women (TW) experience an increased risk of human immunodeficiency virus (HIV) acquisition. This study identified patterns of HIV awareness and prevention strategies used by TW who were not living with HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were drawn from a baseline survey of the LITE Study, a multi\u2010site cohort of TW in Eastern and Southern United States (March 2018\u2013August 2020). We conducted a latent class analysis to identify classes of HIV awareness and prevention strategies among TW who reported past 12\u2010month sexual activity (<jats:italic>N<\/jats:italic> = 958) using 10 variables spanning HIV knowledge, receipt and use of HIV prevention strategies, and sexual practices. Due to differences across the cohort arms, classes were estimated separately for TW enrolled in site\u2010based versus online study arms. We identified demographic characteristics, gender\u2010affirming indicators and HIV vulnerabilities associated with class membership.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four parallel classes emerged: class 1 \u201climited strategies\u2014less sexually active\u201d (15% and 9%, site\u2010based and online, respectively), class 2 \u201climited strategies\u2014insertive sex\u201d (16%\/36%), class 3 \u201climited strategies\u2014receptive sex\u201d (33%\/37%) and class 4 \u201cmultiple strategies\u2014insertive and receptive sex\u201d (36%\/18%). Across all classes, condomless sex, pre\u2010exposure prophylaxis (PrEP)\/post\u2010exposure prophylaxis (PEP) prevention knowledge and awareness were high but reported PrEP\/PEP use was low. Compared with class 1, membership in class 4 was associated with being a person of colour (site\u2010based OR = 2.15, 95% CI = 1.15\u20134.00, online OR = 4.54, 95% CI = 1.09\u201318.81) increased odds of self\u2010perceived medium\u2010to\u2010high HIV risk (site\u2010based OR = 4.12, 95% CI = 2.17\u20137.80, online OR = 11.73, 95% CI = 2.98\u201346.13), sexually transmitted infections (STI) diagnosis (site\u2010based OR = 6.69, 95% CI = 3.42\u201313.10, online OR = 8.46, 95% CI = 1.71\u201341.78), current sex work (site\u2010based OR = 6.49, 95% CI = 2.61\u201316.11, online OR = 10.25, 95% CI = 1.16\u201390.60) and 2\u20134 sexual partners in the last 3 months (site\u2010based OR = 2.61, 95% CI = 1.33\u20135.13). Class 3, compared with class 1, had increased odds of current sex work partners (site\u2010based OR = 3.09, 95% CI = 1.19\u20138.07) and of having 2\u20134 sexual partners in the last 3 months (site\u2010based OR = 3.69, 95% CI = 1.85\u20137.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TW have varied HIV awareness and prevention strategy utilization, with clear gaps in the uptake of prevention strategies. Algorithms derived from latent class membership may be used to tailor HIV prevention interventions for different subgroups and those reached through facility\u2010based or digital methods.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.25999","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T05:49:45Z","timestamp":1665640185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["HIV awareness and prevention strategies among transgender women in the Eastern and Southern United States: findings from the LITE Study"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1217-8466","authenticated-orcid":false,"given":"Rodrigo A.","family":"Aguayo\u2010Romero","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"The Fenway Institute Fenway Health  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1937-4283","authenticated-orcid":false,"given":"Christopher M.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Research Department Whitman\u2010Walker Institute  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2063-1534","authenticated-orcid":false,"given":"Andrea L.","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Cooney","sequence":"additional","affiliation":[{"name":"Department of International Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7460-733X","authenticated-orcid":false,"given":"Kenneth H.","family":"Mayer","sequence":"additional","affiliation":[{"name":"The Fenway Institute Fenway Health  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari L.","family":"Reisner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"The Fenway Institute Fenway Health  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Harvard T.H. 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