{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:52:10Z","timestamp":1769737930327,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AI102634"],"award-info":[{"award-number":["R37 AI102634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P30AI042853"],"award-info":[{"award-number":["P30AI042853"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R37 AI102634"],"award-info":[{"award-number":["R37 AI102634"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Randomized trials and observational studies have consistently reported rates of sustained virological response (SVR), equivalent to hepatitis C virus (HCV) cure, as high as 95% following treatment with direct\u2010acting antiviral (DAA) treatment in individuals with HIV and HCV co\u2010infection. However, large studies assessing whether SVR rates differ according to demographic and clinical strata are lacking. Additionally, the SVR rates reported in the literature were typically computed in non\u2010random samples of individuals with available post\u2010DAA HCV\u2010RNA measures. Here, we aimed to estimate the probability of SVR after DAA treatment initiation in persons with HIV and HCV co\u2010infection overall and by demographic and clinical characteristics with and without adjustment for missing HCV\u2010RNA testing.<\/jats:p><\/jats:sec>Methods<\/jats:title>We included adults with HIV\u2010HCV co\u2010infection who received DAA treatment between 2014 and 2020 in HepCAUSAL, an international collaboration of cohorts from Europe and North America. We estimated the proportions of DAA recipients who had documented SVR (defined as an undetectable HCV\u2010RNA at least 12 weeks after the end of DAA treatment) overall and by strata defined by age, sex, presence of cirrhosis, calendar period, mode of HIV acquisition, CD4 cell count and HCV genotype at DAA treatment. We then compared these rates with those obtained using the parametric g\u2010formula to impute SVR status for individuals with no SVR assessment.<\/jats:p><\/jats:sec>Results and Discussion<\/jats:title>A total of 4527 individuals who initiated DAA treatment (88% males, median [IQR] age 56 [50, 62] years) were included. Of the total of 642 (14%) individuals had no HCV\u2010RNA test on or after 12 weeks after the end of treatment. The overall observed and g\u2010formula imputed SVR rates were 93% (95% CI 93, 94) and 94% (95% CI 92, 95), respectively. SVR estimates were similarly high across all strata. A substantial proportion of individuals who received DAA treatment were never assessed for SVR post\u2010DAA and strategies for more systematic routine HCV\u2010RNA testing should be considered.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our estimates with and without adjustment for missing HCV\u2010RNA testing indicate SVR rates of approximately 95%, like those reported in clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26048","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T14:18:30Z","timestamp":1671805110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sustained virological response after treatment with direct antiviral agents in individuals with HIV and hepatitis C co\u2010infection"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-7830","authenticated-orcid":false,"given":"Sara","family":"Lodi","sequence":"first","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA"},{"name":"CAUSALab, Harvard T.H. 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