{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:05:40Z","timestamp":1790827540221,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2023,5]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Late diagnosis of the human immunodeficiency virus (HIV) is a major concern epidemiologically, socially and for national healthcare systems. Although the association of certain demographics with late HIV diagnosis has been reported in several studies, the association of other factors, including clinical and phylogenetic factors, remains unclear. In the present study, we conducted a nationwide analysis to explore the association of demographics, clinical factors, HIV\u20101 subtypes\/circulating recombinant form (CRFs) and genetic clustering with late HIV diagnosis in Japan, where new infections mainly occur among young men who have sex with men (MSM) in urban areas.<\/jats:p><\/jats:sec>Methods<\/jats:title>Anonymized data on demographics, clinical factors and HIV genetic sequences from 39.8% of people newly diagnosed with HIV in Japan were collected by the Japanese Drug Resistance HIV\u20101 Surveillance Network from 2003 to 2019. Factors associated with late HIV diagnosis (defined as HIV diagnosis with a CD4 count <350 cells\/\u03bcl) were identified using logistic regression. Clusters were identified by HIV\u2010TRACE with a genetic distance threshold of 1.5%.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 9422 people newly diagnosed with HIV enrolled in the surveillance network between 2003 and 2019, 7752 individuals with available CD4 count at diagnosis were included. Late HIV diagnosis was observed in 5522 (71.2%) participants. The overall median CD4 count at diagnosis was 221 (IQR: 62\u2013373) cells\/\u03bcl. Variables independently associated with late HIV diagnosis included age (adjusted odds ratio [aOR] 2.21, 95% CI 1.88\u20132.59, \u226545 vs. \u226429 years), heterosexual transmission (aOR 1.34, 95% CI 1.11\u20131.62, vs. MSM), living outside of Tokyo (aOR 1.18, 95% CI 1.05\u20131.32), hepatitis C virus (HCV) co\u2010infection (aOR 1.42, 95% CI 1.01\u20131.98) and not belonging to a cluster (aOR 1.30, 95% CI 1.12\u20131.51). CRF07_BC (aOR 0.34, 95% CI 0.18\u20130.65, vs. subtype B) was negatively associated with late HIV diagnosis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In addition to demographic factors, HCV co\u2010infection, HIV\u20101 subtypes\/CRFs and not belonging to a cluster were independently associated with late HIV diagnosis in Japan. These results imply the need for public health programmes aimed at the general population, including but not limited to key populations, to encourage HIV testing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26086","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T06:14:02Z","timestamp":1684908842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association of demographics, HCV co\u2010infection, HIV\u20101 subtypes and genetic clustering with late HIV diagnosis: a retrospective analysis from the Japanese Drug Resistance HIV\u20101 Surveillance Network"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2978-0712","authenticated-orcid":false,"given":"Machiko","family":"Otani","sequence":"first","affiliation":[{"name":"AIDS Research Center National Institute of Infectious Diseases Tokyo Japan"},{"name":"Institute of Medical Science University 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