{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:34:20Z","timestamp":1791448460831,"version":"4.3.3"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Long\u2010acting pre\u2010exposure prophylaxis (PrEP) options could overcome barriers to oral PrEP persistence during pregnancy and postpartum. We evaluated long\u2010acting PrEP preferences among oral PrEP\u2010experienced pregnant and postpartum women in South Africa and Kenya, countries with high PrEP coverage with pending regulatory approvals for long\u2010acting injectable cabotegravir and the dapivirine vaginal ring (approved in South Africa, under review in Kenya).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From September 2021 to February 2022, we surveyed pregnant and postpartum women enrolled in oral PrEP studies in South Africa and Kenya. We evaluated oral PrEP attitudes and preferences for long\u2010acting PrEP methods in multivariable logistic regression models adjusting for maternal age and country.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We surveyed 190 women in South Africa (67% postpartum; median age 27 years [IQR = 22\u201332]) and 204 women in Kenya (79% postpartum; median age 29 years [IQR = 25\u201333]). Seventy\u2010five percent of participants reported oral PrEP use within the last 30 days. Overall, forty\u2010nine percent of participants reported negative oral PrEP attributes, including side effects (21% South Africa, 30% Kenya) and pill burden (20% South Africa, 25% Kenya). Preferred PrEP attributes included long\u2010acting method, effectiveness, safety while pregnant and breastfeeding, and free medication. Most participants (75%, South Africa and Kenya) preferred a potential long\u2010acting injectable over oral PrEP, most frequently for a longer duration of effectiveness in South Africa (87% South Africa, 42% Kenya) versus discretion in Kenya (5% South Africa, 49% Kenya). Eighty\u2010seven percent of participants preferred oral PrEP over a potential long\u2010acting vaginal ring, mostly due to concern about possible discomfort with vaginal insertion (82% South Africa, 48% Kenya). Significant predictors of long\u2010acting PrEP preference included past use of injectable contraceptive (aOR = 2.48, 95% CI: 1.34, 4.57), disliking at least one oral PrEP attribute (aOR = 1.72, 95% CI: 1.05, 2.80) and preferring infrequent PrEP use (aOR = 1.58, 95% CI: 0.94, 2.65).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral PrEP\u2010experienced pregnant and postpartum women expressed a theoretical preference for long\u2010acting injectable PrEP over other modalities, demonstrating potential acceptability among a key population who must be at the forefront of injectable PrEP rollout. Reasons for PrEP preferences differed by country, emphasizing the importance of increasing context\u2010specific options and choice of PrEP modalities for pregnant and postpartum women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.26088","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T02:12:01Z","timestamp":1684894321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Preferences and acceptability for long\u2010acting PrEP agents among pregnant and postpartum women with experience using daily oral PrEP in South Africa and Kenya"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-5211","authenticated-orcid":false,"given":"Nafisa J.","family":"Wara","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine at the University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufaro","family":"Mvududu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics School of Public Health University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-1282","authenticated-orcid":false,"given":"Mary M.","family":"Marwa","sequence":"additional","affiliation":[{"name":"Department of Research and Programs Kenyatta National Hospital  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laur\u00e9n","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Global Health University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyiko","family":"Mashele","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics School of Public Health University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Orrell","sequence":"additional","affiliation":[{"name":"Desmond Tutu HIV Centre Institute of Infectious Disease and Molecular Medicine and the Department of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrina","family":"Moucheraud","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management Fielding School of Public Health University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kinuthia","sequence":"additional","affiliation":[{"name":"Department of Research and Programs Kenyatta National Hospital  Nairobi Kenya"},{"name":"Department of Global Health University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"John\u2010Stewart","sequence":"additional","affiliation":[{"name":"Department of Global Health University of Washington  Seattle Washington USA"},{"name":"Department of Epidemiology University of Washington  Seattle Washington USA"},{"name":"Department of Medicine University of Washington  Seattle Washington USA"},{"name":"Department of Pediatrics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon","family":"Myer","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics School of Public Health University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-4574","authenticated-orcid":false,"given":"Risa","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases David Geffen School of Medicine at the University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-7191","authenticated-orcid":false,"given":"Jillian","family":"Pintye","sequence":"additional","affiliation":[{"name":"Department of Global Health University of Washington  Seattle Washington USA"},{"name":"Department of Biobehavioral Nursing and Health Informatics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dvora L. 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