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Demand creation for LA PrEP and education about new LA PrEP options should be co\u2010developed with communities and be positively framed. Client\u2010facing clinical decision support tools provide information about HIV prevention and PrEP options in non\u2010technical ways and can support their informed decision\u2010making about PrEP. Training for providers is needed to increase their ability to ask about sexual and drug use behaviours in a non\u2010judgmental and comfortable manner as part of risk assessment, discuss harm reduction strategies and counsel about available PrEP options that fit clients\u2019 circumstances and needs. PrEP adherence support should include supportive counselling and be tailored to address an individual's particular barriers and needs. Reminders through text messaging or calls can foster PrEP persistence, given the narrow the window around dosing for injectable cabotegravir. Strategies are needed to expand PrEP delivery options, including telePrEP, pharmacy\u2010based PrEP, key population\u2010led services and mobile venues. Integrated delivery models are needed which include sexually transmitted infection testing and treatment, contraception for cis\u2010women not desiring to become pregnant, PrEP for pregnant women in high HIV prevalence settings, and gender\u2010affirming hormones and support for transgender persons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The outcome of expanding PrEP options through LA PrEP formulations is to increase PrEP coverage, adherence, persistence and effectiveness by offering a choice of PrEP that meets the needs of persons who would benefit from PrEP. The lessons learned from the delivery of oral PrEP about demand creation, informed client decision\u2010making, provider training, adherence support and service delivery model are relevant to the delivery of LA PrEP and integration with other services.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26103","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T07:09:29Z","timestamp":1689232169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Preparing for long\u2010acting PrEP delivery: building on lessons from oral PrEP"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-3419","authenticated-orcid":false,"given":"Connie","family":"Celum","sequence":"first","affiliation":[{"name":"Departments of Global Health Medicine, and Epidemiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Grinsztejn","sequence":"additional","affiliation":[{"name":"Evandro Chagas National Institute of Infectious Diseases\u2010Fiocruz  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-0933","authenticated-orcid":false,"given":"Kenneth","family":"Ngure","sequence":"additional","affiliation":[{"name":"School of Public Health Jomo Kenyatta University of Agriculture and Technology  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108524"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202614"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61127-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402269"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110711"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00133-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00074-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003492"},{"key":"e_1_2_7_11_1","unstructured":"AVAC.PxWire: a quarterly update on HIV prevention research.2022.https:\/\/www.avac.org\/pxwire. 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