{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:36:03Z","timestamp":1792802163689,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tuberculosis (TB) causes one\u2010third of HIV\u2010related deaths worldwide, making TB preventive treatment (TPT) a critical element of HIV programmes. Approximately 16% of people living with HIV (PLHIV) on antiretrovirals in Zimbabwe are enrolled in the Fast Track (FT) differentiated service delivery model, which includes multi\u2010month dispensing of antiretrovirals and quarterly health facility (HF) visits. We assessed the feasibility and acceptability of utilizing FT to deliver 3HP (3 months of once\u2010weekly rifapentine and isoniazid) for TPT by aligning TPT and HIV visits, providing multi\u2010month dispensing of 3HP, and using phone\u2010based monitoring and adherence support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited a purposive sample of 50 PLHIV enrolled in FT at a high\u2010volume HF in urban Zimbabwe. At enrolment, participants provided written informed consent, completed a baseline survey, and received counselling, education and a 3\u2010month supply of 3HP. A study nurse mentor called participants at weeks 2, 4 and 8 to monitor and support adherence and side effects. When participants returned for their routine 3\u2010month FT visit, they completed another survey, and study staff conducted a structured medical record review. In\u2010depth interviews were conducted with providers who participated in the pilot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants were enrolled between April and June 2021 and followed through September 2021. Median age = 32 years (IQR 24,41), 50% female, median time in FT 1.8 years (IQR 0.8,2.7). Forty\u2010eight participants (96%) completed 3HP in 13 weeks; one completed in 16 weeks, and one stopped due to jaundice. Most participants (94%) reported \u201calways\u201d or \u201calmost always\u201d taking 3HP correctly. All reported they were very satisfied with the counselling, education, support and quality of care they received from providers and FT service efficiency. Almost all (98%) said they would recommend it to other PLHIV. Challenges reported included pill burden (12%) and tolerability (24%), but none had difficulty with phone\u2010based counselling or wished for additional HF\u2010based visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Using FT to deliver 3HP was feasible and acceptable. Some reported tolerability challenges but 98% completed 3HP, and all appreciated the efficiency of aligning TPT and HIV HF visits, multi\u2010month dispensing and phone\u2010based counselling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Scaling up this approach could expand TPT coverage in Zimbabwe.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26105","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T18:55:03Z","timestamp":1687287303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Integrating 3HP\u2010based tuberculosis preventive treatment into Zimbabwe's Fast Track HIV treatment model: experiences from a pilot study"],"prefix":"10.1002","volume":"26","author":[{"given":"Munyaradzi P.","family":"Mapingure","sequence":"first","affiliation":[{"name":"ICAP Zimbabwe  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8652-0784","authenticated-orcid":false,"given":"Jennifer M.","family":"Zech","sequence":"additional","affiliation":[{"name":"ICAP at Columbia University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Hirsch\u2010Moverman","sequence":"additional","affiliation":[{"name":"ICAP at Columbia University  New York City New York USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-2610","authenticated-orcid":false,"given":"Martin","family":"Msukwa","sequence":"additional","affiliation":[{"name":"ICAP at Columbia University  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Howard","sequence":"additional","affiliation":[{"name":"ICAP at Columbia University  New York City New York USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatenda","family":"Makoni","sequence":"additional","affiliation":[{"name":"Zimbabwe Network for People Living with HIV (ZNNP+)  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clorata","family":"Gwanzura","sequence":"additional","affiliation":[{"name":"Ministry of Health and Child Care (MoHCC)  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsitsi","family":"Apollo","sequence":"additional","affiliation":[{"name":"Ministry of Health and Child Care (MoHCC)  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sandy","sequence":"additional","affiliation":[{"name":"Ministry of Health and Child Care (MoHCC)  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-4429","authenticated-orcid":false,"given":"Godfrey N.","family":"Musuka","sequence":"additional","affiliation":[{"name":"International Initiative for Impact Evaluation (3ie)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Rabkin","sequence":"additional","affiliation":[{"name":"ICAP at Columbia University  New York City New York USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Global tuberculosis report 2022","author":"World Health Organization","year":"2021"},{"key":"e_1_2_12_3_1","unstructured":"World Health Organization.HIV\u2010associated TB.2018[cited 2022 Feb 12]https:\/\/www.who.int\/tb\/areas\u2010of\u2010work\/tb\u2010hiv\/tbhiv_factsheet.pdf?ua=1"},{"key":"e_1_2_12_4_1","unstructured":"PHIA Project.Zimbabwe Summary Sheet.2020[cited 2022 Nov 21]https:\/\/phia.icap.columbia.edu\/zimbabwe\u20102020\u2010summary\u2010sheet"},{"key":"e_1_2_12_5_1","unstructured":"World Health Organization.Tuberculosis profile: Zimbabwe. 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