{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:52Z","timestamp":1786978072800,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN\u2010143218"],"award-info":[{"award-number":["FDN\u2010143218"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Since many countries in sub\u2010Saharan Africa are willing to implement HIV oral pre\u2010exposure prophylaxis (PrEP) for men who have sex with men (MSM), data are needed to assess its feasibility and relevance in real life. The study objectives were to assess drug uptake, adherence, condom use and number of sexual partners, HIV incidence and trends in the prevalence of gonorrhoea and chlamydia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this oral PrEP demonstration study conducted prospectively in Benin, a combination of tenofovir disoproxil fumarate\u2010TDF 300 mg and emtricitabine\u2010FTC 200 mg (TDF\u2010FTC) was offered daily or on\u2010demand to MSM. Participants were recruited from 24 August to 24 November 2020 and followed over 12 months. At enrolment, month\u20106 and month\u201012, participants answered to a face\u2010to\u2010face questionnaire, underwent a physical examination and provided blood samples for HIV, gonorrhoea and chlamydia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 204 HIV\u2010negative men initiated PrEP. The majority of them (80%) started with daily PrEP. Retention rates at month\u20103, 6, 9 and 12 were 96%, 88%, 86% and 85%, respectively. At month\u20106 and month\u201012, respectively, 49% and 51% of the men on daily PrEP achieved perfect adherence (self\u2010reported), that is seven pills taken during the last week. For event\u2010driven PrEP, the corresponding proportions for perfect adherence (last seven at\u2010risk sexual episodes covered) were 81% and 80%, respectively. The mean number (standard deviation) of male sexual partners over the last 6 months was 2.1 (1.70) at baseline and 1.5 (1.27) at month\u201012 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value for trend &lt;0.001). Consistent condom use during the last 6 months was 34% (enrolment), 37% (month\u20106) and 36% (month\u201012). Three HIV seroconversions (2\u2010daily and 1\u2010event\u2010driven) were recorded. Crude HIV incidence (95% confidence interval) was 1.53 (0.31\u22124.50)\/100 person\u2010years.\n                      <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                      and\/or\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                      prevalence at the anal and\/or pharyngeal and\/or urethral sites was 28% at baseline and 18% at month\u201012 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value = 0.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In West Africa, oral PrEP introduction in routine practice as a component of a holistic HIV prevention package is feasible and may not result in a significant increase in condomless sex among MSM. Since HIV incidence was still higher, additional interventions, such as culturally tailored adherence counselling, may be needed to optimize the benefits of PrEP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.26130","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T05:59:17Z","timestamp":1686549557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pre\u2010exposure prophylaxis in real life: experience from a prospective, observational and demonstration project among men who have sex with men in Benin, West Africa"],"prefix":"10.1002","volume":"26","author":[{"given":"Souleymane","family":"Diabat\u00e9","sequence":"first","affiliation":[{"name":"Centre de recherche du CHU de Qu\u00e9bec Universit\u00e9 Laval  Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"D\u00e9partement de m\u00e9decine sociale et pr\u00e9ventive Universit\u00e9 Laval  Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"UFR Sciences m\u00e9dicales Universit\u00e9 Alassane Ouattara  Bouak\u00e9 C\u00f4te d'Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"B\u00e9hanzin","sequence":"additional","affiliation":[{"name":"\u00c9cole nationale de formation des techniciens sup\u00e9rieurs en sant\u00e9 publique et en surveillance \u00e9pid\u00e9miologique Universit\u00e9 de Parakou  Parakou Benin"},{"name":"Organisation pour la Promotion de la Sant\u00e9 et le D\u00e9veloppement communautaire  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernand A.","family":"Gu\u00e9dou","sequence":"additional","affiliation":[{"name":"Organisation pour la Promotion de la Sant\u00e9 et le D\u00e9veloppement communautaire  Cotonou Benin"},{"name":"Dispensaire IST Centre de sant\u00e9 communal de Cotonou 1  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Goma\u2010Mats\u00e9ts\u00e9","sequence":"additional","affiliation":[{"name":"Dispensaire IST Centre de sant\u00e9 communal de Cotonou 1  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Olodo","sequence":"additional","affiliation":[{"name":"Dispensaire IST Centre de sant\u00e9 communal de Cotonou 1  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Aza\u2010Gnandji","sequence":"additional","affiliation":[{"name":"Dispensaire IST Centre de sant\u00e9 communal de Cotonou 1  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Dossouvo","sequence":"additional","affiliation":[{"name":"Dispensaire IST Centre de sant\u00e9 communal de Cotonou 1  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Akpaka","sequence":"additional","affiliation":[{"name":"Benin Synergie Plus  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyote","family":"Chagas","sequence":"additional","affiliation":[{"name":"R\u00e9seau Sida B\u00e9nin  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flore","family":"Gangbo","sequence":"additional","affiliation":[{"name":"Programme Sant\u00e9 de Lutte contre le Sida  Cotonou Benin"},{"name":"Facult\u00e9 des sciences de la sant\u00e9 Universit\u00e9 d'Abomey\u2010Calavi  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djimon Marcel","family":"Zannou","sequence":"additional","affiliation":[{"name":"Facult\u00e9 des sciences de la sant\u00e9 Universit\u00e9 d'Abomey\u2010Calavi  Cotonou Benin"},{"name":"Centre national hospitalier universitaire HMK  Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Alary","sequence":"additional","affiliation":[{"name":"Centre de recherche du CHU de Qu\u00e9bec Universit\u00e9 Laval  Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"D\u00e9partement de m\u00e9decine sociale et pr\u00e9ventive Universit\u00e9 Laval  Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"Institut national de sant\u00e9 publique  Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"UNAIDS.UNAIDS Data 2021.Geneva:UNAIDS;2021."},{"key":"e_1_2_11_3_1","unstructured":"UNAIDS.UNAIDS Data 2022.Geneva:UNAIDS;2022."},{"key":"e_1_2_11_4_1","volume-title":"Module 1: Clinical","author":"WHO","year":"2017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0872-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3463-4"},{"key":"e_1_2_11_7_1","unstructured":"AVAC.PrEP initiations by country worldwide. AVAC Global Advocacy for HIV Prevention. [Cited 2022 Nov 05] Available at:https:\/\/www.avac.org\/infographic\/prep\u2010initiations\u2010country\u2010worldwide."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30156-X"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1086"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1810743"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020063"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25208"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2019.1622643"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09363-4"},{"key":"e_1_2_11_15_1","unstructured":"BeSyP.BeSyP en Marche: rapport illustr\u00e9 du mapping des hommes qui ont des rapports sexuels avec des hommes au B\u00e9nin.Cotonou Benin:R\u00e9seau B\u00e9nin Synergie Plus (BeSyP);2017."},{"key":"e_1_2_11_16_1","unstructured":"PlanInternational B\u00e9nin.Enqu\u00eate de Surveillance de Deuxi\u00e8me G\u00e9n\u00e9ration (ESDG) du VIH et des IST aupr\u00e8s des Hommes ayant des Rapports Sexuels avec les Hommes (HSH) au B\u00e9nin.B\u00e9nin: Rapport de surveillance de routine des IST\/VIH au sein des HSH par Plan Int\u2010B\u00e9nin \u00e9dition 2017; Rapport final. Cotonou 2017."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jssam\/smw012"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00005-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2020.1739207"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2013.301506"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209484"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25827"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-015-1238-0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003492"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-022-03685-7"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2020.1778628"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004006"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108524"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-017-1701-1"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01108-x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2012.672717"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2019.1612023"}],"container-title":["Journal of the International AIDS Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jia2.26130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T12:25:32Z","timestamp":1692447932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jia2.26130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/jia2.26130"],"URL":"https:\/\/doi.org\/10.1002\/jia2.26130","archive":["Portico"],"relation":{},"ISSN":["1758-2652","1758-2652"],"issn-type":[{"value":"1758-2652","type":"print"},{"value":"1758-2652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e26130"}}