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Pharmacy providers screened clients interested in PrEP for HIV risk, then used a prescribing checklist to identify clients without medical conditions that might contraindicate PrEP safety, counsel them on PrEP use and safety, conduct provider\u2010assisted HIV self\u2010testing and dispense PrEP. For complex clinical cases, a remote clinician was available for consultation. Clients who did not meet the checklist criteria were referred to public facilities for free services delivered by clinicians. Pharmacy providers dispensed a 1\u2010month PrEP supply at initiation and a 3\u2010month supply thereafter at a client fee of 300 KES (\u223c$3 USD) per visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From November 2020 to October 2021, pharmacy providers screened 575 clients, identified 476 who met the prescribing checklist criteria and initiated 287 (60%) on PrEP. Among pharmacy PrEP clients, the median age was 26 years (IQR 22\u201333) and 57% (163\/287) were male. The prevalence of behaviours associated with HIV risk among clients was high; 84% (240\/287) reported sexual partners with unknown HIV status and 53% (151\/287) reported multiple sexual partners (past 6 months). PrEP continuation among clients was 53% (153\/287) at 1 month, 36% (103\/287) at 4 months and 21% (51\/242) at 7 months. During the pilot observation period, 21% (61\/287) of clients stopped and restarted PrEP and overall pill coverage was 40% (IQR 10%\u201370%). Nearly, all pharmacy PrEP clients (\u226596%) agreed or strongly agreed with statements regarding the acceptability and appropriateness of pharmacy\u2010delivered PrEP services.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings from this pilot suggest that populations at HIV risk frequently visit private pharmacies and PrEP initiation and continuation at pharmacies is similar to or exceeds that at public healthcare facilities. Private pharmacy\u2010based PrEP delivery, conducted entirely by private\u2010sector pharmacy staff, is a promising new delivery model that has the potential to expand PrEP reach in Kenya and similar settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26131","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T10:07:52Z","timestamp":1686564472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Stand\u2010alone model for delivery of oral HIV pre\u2010exposure prophylaxis in Kenya: a single\u2010arm, prospective pilot evaluation"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-8836","authenticated-orcid":false,"given":"Katrina F.","family":"Ortblad","sequence":"first","affiliation":[{"name":"Public Health Sciences Division Fred Hutchinson Cancer Center  Seattle Washington 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