{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:52:12Z","timestamp":1793796732928,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Simplified hepatitis C virus (HCV) diagnostic strategies have the potential to improve HCV diagnoses and treatment. We aimed to investigate the impact of simplified HCV diagnostic strategies on HCV incidence and its effect on HCV diagnosis and treatment among men who have sex with men (MSM) regardless of HIV status and use of HIV pre\u2010exposure prophylaxis (PrEP) in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A compartmental deterministic model was developed to describe the natural history of HCV disease progression, the HCV care cascade and the HIV status and PrEP using among MSM. The model was calibrated to available data for HCV and HIV epidemiology and population demographics in Taiwan. We simulated the epidemic from 2004 and projected the impact of simplified testing strategies on the HCV epidemic among MSM over 2022\u20132030.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Under the current testing approach in Taiwan, total HCV incidence would increase to 12.6 per 1000 person\u2010years among MSM by 2030. Single\u2010visit point\u2010of\u2010care RNA testing had the largest impact on reducing the number of new HCV infections over 2022\u20132030, with a 31.1% reduction (interquartile range: 24.9%\u221232.8%). By 2030, single\u2010visit point\u2010of\u2010care HCV testing improved HCV diagnosis to 90.9%, HCV treatment to 87.7% and HCV cure to 81.5% among MSM living with HCV. Compared to status quo, prioritized simplified HCV testing for PrEP users and MSM living with diagnosed HIV had considerable impact on the broader HCV epidemic among MSM. A sensitivity analysis suggests that reinfection risk would have a large impact on the effectiveness of each point\u2010of\u2010care testing scenario.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simplified HCV diagnostic strategies could control the ongoing HCV epidemic and improve HCV testing and treatment among Taiwanese MSM. Single\u2010visit point\u2010of\u2010care RNA testing would result in large reductions in HCV incidence and prevalence among MSM. Efficient risk\u2010reduction strategies will need to be implemented alongside point\u2010of\u2010care testing to achieve HCV elimination among MSM in Taiwan.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26251","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T08:09:14Z","timestamp":1714637354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of simplified HCV diagnostic strategies on the HCV epidemic among men who have sex with men in the era of HIV oral pre\u2010exposure prophylaxis in Taiwan: a modelling study"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5085-1976","authenticated-orcid":false,"given":"Huei\u2010Jiuan","family":"Wu","sequence":"first","affiliation":[{"name":"The Kirby Institute UNSW  Sydney New South Wales Australia"},{"name":"Department of Public Health College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophy TingFang","family":"Shih","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya L.","family":"Applegate","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisoo A.","family":"Kwon","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan B.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Grebely","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-0483","authenticated-orcid":false,"given":"Richard T.","family":"Gray","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32835c2120"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190340"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30303-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316366"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw203"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00471-4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis044"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00346-6"},{"key":"e_1_2_12_11_1","volume-title":"Updated recommendations on HCV simplified service delivery and HCV diagnostics: policy brief","year":"2022"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25062"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.11.010"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz367"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx075"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz164"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321744"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0979-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13503"},{"key":"e_1_2_12_20_1","unstructured":"WuJHJ.Simplified\u2010HCV\u2010testing\u2010model [Internet].2023[cited 2024 Feb 6]. 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