{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:01:50Z","timestamp":1791003710752,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Int AIDS Soc."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To assess the effectiveness of novel HIV curative strategies, \u201ccure\u201d trials require periods of closely monitored antiretroviral therapy (ART) analytical treatment interruptions (ATIs). We performed a systematic review and meta\u2010analysis to identify the impact of ATI with or without novel therapeutics in cure\u2010related studies on the time to viral re\u2010suppression following ART restart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medline, Embase and Web of Science databases were searched for human studies involving ATIs from 1 January 2015 till 22 April 2024. The primary outcome was time to first viral re\u2010suppression (plasma HIV viral load [VL] &lt;50 copies\/ml) stratified by receipt of interventional drug with ATI (IA) or ATI\u2010only groups. Random\u2010effects proportional meta\u2010analysis and multivariable Cox proportional hazards analysis were performed using R.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1073 studies screened, 13 were included that met the inclusion criteria with VL data available after restarting ART (\n                      <jats:italic>n<\/jats:italic>\n                      = 213 participants). There was no difference between time to viral suppression in IA or ATI\u2010only cohorts (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.22). For 87% of participants, viral suppression within 12 weeks of ART restart was achieved, and all eventually had at least one VL &lt;50 copies\/ml during follow\u2010up. After adjusting for covariables, while participants in the IA cohort were associated with less rapid suppression (adjusted hazard ratio [aHR] 0.61, 95% CI 0.40\u20130.94,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.026), other factors include greater log VL at ART restart (aHR 0.56, 95% CI 0.46\u20130.68,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), duration since HIV diagnosis (aHR 0.93, 95% CI 0.89\u20130.96) and longer intervals between HIV VL monitoring (aHR 0.66, 95% CI 0.59\u20130.74,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). However, the use of integrase inhibitors was associated with more rapid viral suppression (aHR 1.74, 95% CI 1.16\u20132.59).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>When designing studies involving ATIs, information on time to viral re\u2010suppression after restarting ART is important to share with participants, and should be regularly monitored and reported, to assess the impact and safety of specific trial interventions in ATI studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The majority of participants achieved viral suppression after restarting ART in ATI studies. ART regimens containing integrase inhibitors and frequent VL monitoring should be offered for people restarting ART after ATI studies to ensure rapid re\u2010suppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jia2.26349","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:19:35Z","timestamp":1724026775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The impact of analytical treatment interruptions and trial interventions on time to viral re\u2010suppression in people living with HIV restarting ART in cure\u2010related clinical studies: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-0070","authenticated-orcid":false,"given":"Ming Jie","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Imperial College London London 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Scheerder","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Ghent University Hospital Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Riley","sequence":"additional","affiliation":[{"name":"Center for Cellular Immunotherapies Department of Microbiology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Tebas","sequence":"additional","affiliation":[{"name":"Center for Cellular Immunotherapies Department of Microbiology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-0259","authenticated-orcid":false,"given":"Jesper","family":"Gunst","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aarhus University Hospital Aarhus 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