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Initiating and continuing PrEP remotely via online pharmacies is a promising strategy to expand PrEP uptake, but little is known about potential users\u2019 preferences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a discrete choice experiment (DCE) to assess preferences for online pharmacy PrEP services. We partnered with MYDAWA, an online pharmacy in Nairobi, Kenya. Eligibility criteria were: \u226518 years, not known HIV positive, interested in PrEP. The DCE contained four attributes: PrEP eligibility assessment (online self\u2010assessed, guided), HIV test type (provider administered, oral HIV self\u2010test [HIVST], blood\u2010based HIVST), clinical consultation (remote, in\u2010person) and user support options (text messages, phone\/video call, email). Additionally, participants indicated whether they were willing to uptake their selected service. The survey was advertised on MYDAWA's website; interested participants met staff in\u2010person at a convenient location to complete the survey from 1 June to 20 November 2022. We used conditional logit modelling with an interaction by current PrEP use to estimate overall preferences and latent class analysis (LCA) to assess preference heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 772 participants completed the DCE; the mean age was 25 years and 54% were female. Most participants indicated a willingness to acquire online PrEP services, with particularly high demand among PrEP\u2010naive individuals. Overall, participants preferred remote clinical consultation, HIV self\u2010testing, online self\u2010assessment and phone call user support. The LCA identified three subgroups: the \u201cprefer online PrEP with remote components\u201d group (60.3% of the sample) whose preferences aligned with the main analysis, the \u201cprefer online PrEP with in\u2010person components\u201d group (20.7%), who preferred in\u2010person consultation, provider\u2010administered HIV testing, and guided assessment, and the \u201cprefer remote PrEP (18.9%)\u201d group who preferred online PrEP services only if they were remote.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Online pharmacy PrEP is highly acceptable and may expand PrEP coverage to those interested in PrEP but not accessing services. Most participants valued privacy and autonomy, preferring HIVST and remote provider interactions. However, when needing support for questions regarding PrEP, participants preferred phone\/SMS contact with a provider. One\u2010fifth of participants preferred online PrEP with in\u2010person components, suggesting that providing multiple options can increase uptake.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jia2.26356","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:35:58Z","timestamp":1728567358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Preferences for pre\u2010exposure prophylaxis delivery via online pharmacy among potential users in Kenya: a discrete choice experiment"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-6354","authenticated-orcid":false,"given":"Enrique M.","family":"Saldarriaga","sequence":"first","affiliation":[{"name":"The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Chen","sequence":"additional","affiliation":[{"name":"The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalina A.","family":"Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Diseases Division (VIDD) Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Global Health University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Thuo","sequence":"additional","affiliation":[{"name":"Partners in Health and Research Development Centre for Clinical Research, Kenya Medical Research Institute  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Kiptinness","sequence":"additional","affiliation":[{"name":"Partners in Health and Research Development Centre for Clinical Research, Kenya Medical Research Institute  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fern","family":"Terris\u2010Prestholt","sequence":"additional","affiliation":[{"name":"Department of Global Health and Development Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Stergachis","sequence":"additional","affiliation":[{"name":"The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute University of Washington  Seattle Washington USA"},{"name":"Department of Global Health University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-5528","authenticated-orcid":false,"given":"Melissa Latigo","family":"Mugambi","sequence":"additional","affiliation":[{"name":"Department of Global Health University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-0933","authenticated-orcid":false,"given":"Kenneth","family":"Ngure","sequence":"additional","affiliation":[{"name":"Department of Global Health University of Washington  Seattle Washington USA"},{"name":"School of Public Health Jomo Kenyatta University of Agriculture and Technology  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-8836","authenticated-orcid":false,"given":"Katrina F.","family":"Ortblad","sequence":"additional","affiliation":[{"name":"Public Health Science Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-1561","authenticated-orcid":false,"given":"Monisha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Global Health University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26115"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-231"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.21134"},{"key":"e_1_2_11_5_1","unstructured":"KyongoJK.How long will they take it? 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